Micro-imaging of the intratumoral boron distribution in the neutron capture therapy
| Project/Area Number |
26870563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
Medical Physics and Radiological Technology
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| Research Institution | Kyorin University |
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Principal Investigator |
Sato Eisuke 杏林大学, 保健学部, 助教 (00439150)
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| Research Collaborator |
ISOBE Tomonori 筑波大学, 医学医療系, 准教授 (70383643)
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 准教授 (30375505)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | MRI / 1H-MRS / BNCT / MR diffusion / MR Spectroscopy / BPA |
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| Outline of Final Research Achievements |
The effect of treatment of BNCT greatly depends on quantity of the boron taken in by intratumorale boron and the distribution. A purpose of this research is to establish the micro-imaging techniques of the intratumoral boron distribution.
Firstly I classified the Cho/Cr value acquired using 1H-MRS in four stages according to the grade of the brain tumor. And Cho/Cr value allotted to four colors was imaged in each voxel. As a result, the image of the Cho/Cr value matched up to a T2-weighted image. It means that the border with a normal region and the tumor region was distinguished clearly. Furthermore, it was confirmed that the intratumoral grade was heterogeneous.
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Report
(4 results)
Research Products
(3 results)
