| Project/Area Number |
26870569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Sato Takashi 慶應義塾大学, 医学部, 共同研究員 (20464836)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺がん / DNAメチル化 / エピジェネティクス |
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| Outline of Final Research Achievements |
Lung cancer is the leading cause of cancer-related death worldwide. It is known that epigenetic changes contribute to human carcinogenesis. We examined candidate genes which were obtained from genome-wide DNA methylation analysis. mRNA expression of PTPRH, one of the candidate genes, were upregulated in non-small cell lung cancer tissues compared with non-cancerous lung tissues and inversly correlated with DNA methylation levels in a cohort of lung adenocarcinoma patients. DNA-demethylating treatment of cell lines restored mRNA
PTPRH expression levels, suggesting that PTPRH gene expression was regulated by DNA hypomethylation. Furthermore, we identified the DNA methylation status of PTPRH as a novel prognostic factor for lung adenocarcinoma.
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