| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Invasive examination such as liver biopsy and endoscopic examination is necessary for assessment of liver diseases. In the current study, we performed liver and spleen stiffness measurements using ultrasound apparatus for children with chronic liver disease including liver transplantation and we compared liver and spleen stiffness measurements with the results of liver biopsy and endoscopic examinations. As a result, we found that liver and spleen stiffness measurements were useful for predicting liver fibrosis on liver biopsy examinations and esophageal varices on endoscopic examinations.
In addition, it has been known that unexplained liver fibrosis occurs after pediatric liver transplantation. We conducted a study with the cooperation of the living donor and we could find that the anti-donor specific antibody is one of the causes of liver fibrosis after pediatric liver transplantation.
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