Establishment of diagnosis and treatment for graft fibrosis long after pediatric liver transplantation
| Project/Area Number |
26870570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
Tomita Hirofumi 慶應義塾大学, 医学部(信濃町), 共同研究員 (50464954)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 小児肝移植 / 肝線維化 / 抗ドナー抗体 / 非侵襲的診断 / ARFI / 肝硬度 / 脾硬度 / 門脈圧亢進症 |
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| Outline of Final Research Achievements |
Invasive examination such as liver biopsy and endoscopic examination is necessary for assessment of liver diseases. In the current study, we performed liver and spleen stiffness measurements using ultrasound apparatus for children with chronic liver disease including liver transplantation and we compared liver and spleen stiffness measurements with the results of liver biopsy and endoscopic examinations. As a result, we found that liver and spleen stiffness measurements were useful for predicting liver fibrosis on liver biopsy examinations and esophageal varices on endoscopic examinations.
In addition, it has been known that unexplained liver fibrosis occurs after pediatric liver transplantation. We conducted a study with the cooperation of the living donor and we could find that the anti-donor specific antibody is one of the causes of liver fibrosis after pediatric liver transplantation.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study2016
Author(s)
Hirofumi Tomita, Kiyoshi Ohkuma, YoheiMasugi, Naoki Hosoe, Ken Hoshino, Yasushi Fuchimoto, Akihiro Fujino, Takahiro Shimizu, Mototoshi Kato, Takumi Fujimura, Hideo Ishihama, Nobuhiro Takahashi, Yutaka Tanami, Hirotoshi Ebinuma, Hidetsugu Saito, Michiie Sakamoto, Miwako Nakano, and Tatsuo Kuroda
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Journal Title
Pediatric Radiology
Volume: 46
Issue: 10
Pages: 1409-1417
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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