| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Stroke is a leading cause of death and disability worldwide, and approximately 70% of stroke are ischemic stroke. The approved treatments for ischemic stroke are limited within the early time after stroke onset. There is a need for an efficacious therapy which can be administered in the delayed phase of ischemic stroke. Post-ischemic inflammation is an essential step in the pathologies of ischemic stroke. The secondary progression of the infarct lesion by inflammation is directly linked to the prognosis of ischemic stroke patients. In this research, we clarified the molecular mechanisms in the resolution of cerebral post-ischemic inflammation to establish novel therapeutic strategies for ischemic stroke.
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