Neurorepair after ischemic stroke by hematopoietic cells
Project/Area Number |
26870571
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
General internal medicine(including psychosomatic medicine)
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 脳梗塞 / 炎症 / マクロファージ / 自然免疫 / 脳虚血後炎症 / 炎症細胞 / 修復細胞 / 修復誘導因子 |
Outline of Final Research Achievements |
Stroke is a leading cause of death and disability worldwide, and approximately 70% of stroke are ischemic stroke. The approved treatments for ischemic stroke are limited within the early time after stroke onset. There is a need for an efficacious therapy which can be administered in the delayed phase of ischemic stroke. Post-ischemic inflammation is an essential step in the pathologies of ischemic stroke. The secondary progression of the infarct lesion by inflammation is directly linked to the prognosis of ischemic stroke patients. In this research, we clarified the molecular mechanisms in the resolution of cerebral post-ischemic inflammation to establish novel therapeutic strategies for ischemic stroke.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Smad2 and Smad3 inversely regulate TGF-β autoinduction in Clostridium butyricum-activated dendritic cells.2015
Author(s)
Kashiwagi K, Morita R, Schichita T, Komai K, Saeki K, Matsumoto M, Takeda K, Nomura M, Hayashi A, Kanai T, Yoshimura A
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Journal Title
Immunity
Volume: 43
Issue: 1
Pages: 65-79
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 脳梗塞の炎症とその収束2015
Author(s)
七田 崇、伊藤美菜子、大星博明、吉村昭彦
Organizer
第27回脳循環代謝学会
Place of Presentation
富山国際会議場(富山県富山市)
Year and Date
2015-10-30
Related Report
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[Presentation] 脳梗塞の炎症とその収束2015
Author(s)
七田 崇、伊藤美菜子、吉村昭彦
Organizer
第36回日本炎症再生学会
Place of Presentation
虎ノ門ヒルズフォーラム(東京都港区)
Year and Date
2015-07-21
Related Report
Invited
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