Neural mechanisms of language disorders in patients with a glioma: Evidence from a neuroimaging study
| Project/Area Number |
26870582
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
Basic / Social brain science
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
KINNO RYUTA 昭和大学, 医学部, 講師 (70439397)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 失語症 / 統語処理 / 神経膠腫 / 神経心理学 / 脳科学 / 機能連関 / 統語理解障害 / 脳内ネットワーク / functional MRI / 拡散テンソル画像 / 機能的結合性 / functional ＭＲＩ |
|---|
| Outline of Final Research Achievements |
Linguistic information is processed at distinct levels from words to sentences and discourses. We have used functional magnetic resonance imaging (fMRI), and shown that the left inferior frontal gyrus (L. IFG) and the left lateral premotor cortex (L. LPMC) are critically involved in syntactic processing. Moreover, we have demonstrated that a glioma in the L. IFG or L. LPMC is sufficient to cause asyntactic comprehension. Detailed analyses of abnormal activation patterns in the patients with asyntactic comprehension revealed three syntax-related networks. In addition, these analyses clarified that asyntactic comprehension are associated with the global reorganization of functionally distinct networks, differentially contributed to syntax-related functions. These results suggest the importance of the neural networks for syntactic processing.
|
Report
(4 results)
Research Products
(18 results)
-
[Journal Article] Difficulty in identification of the frontal language area in patients with dominant frontal gliomas that involve the pars triangularis.2016
Author(s)
Saito, T., Y. Muragaki, T. Maruyama, M. Tamura, M. Nitta, S. Tsuzuki, Y. Konishi, K. Kamata, R. Kinno, K. L. Sakai, H. Iseki and T. Kawamata
-
Journal Title
J Neurosurg
Volume: Posted online on 22 Jan
Issue: 4
Pages: 1-9
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] 進行性非流暢性/失文法性失語の脳血流部位に関する研究2016
Author(s)
金野 竜太, 黒川 信二, 大湾 喜行, 二村 明憲, 四郎丸 あずさ, 笠井 英世, 黒田 岳志, 矢野 怜, 石垣 征一郎, 村上 秀友, 小野 賢二郎
Organizer
第21回日本神経精神医学会
Place of Presentation
熊本
Year and Date
2016-09-17
Related Report
-
-
-
-
[Presentation] 進行性非流暢性失語の脳血流部位に関する研究2016
Author(s)
金野 竜太, 城井 義隆, 笠井 英世, 大湾 喜行, 黒川 信二, 砂川 優, 山本 泰漢, 関川 高志, 成島 道昭, 衣笠 えり子
Organizer
第113回日本内科学会講演会
Place of Presentation
東京
Year and Date
2016-04-15
Related Report
-
-
-
-
-
-
-
