Analysis of mechanism of osteoblastic ossification on anodically oxidized titanium plates
| Project/Area Number |
26870583
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
Suzuki Dai 昭和大学, 歯学部, 助教 (00585797)
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| Research Collaborator |
SHIBATA Yo 昭和大学, 歯学部 歯科保存学講座 歯科理工学部門, 講師 (30327936)
YAMADA Atsushi 昭和大学, 歯学部 口腔生化学講座, 講師 (50407558)
TAKAMI Masamichi 昭和大学, 歯学部 歯科薬理学講座, 教授 (80307058)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨芽細胞 / 陽極酸化チタン / 石灰化 / 歯科インプラント / 再生歯学 |
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| Outline of Final Research Achievements |
Our previous results showed enhanced ossification of osteoblasts cultured on anodically oxidized titanium (Ao-Ti) plates. In the present study, we found that the mRNA expression of non-collagenous protein-related genes, which are involved in ossification, in osteoblasts cultured on those plates was increased as compared with those on untreated polished titanium plates. On the other hand, when osteoblasts were cultured in the presence of titanium plates without direct contact there was no significant difference regarding mRNA expression of those genes between culture with Ao-Ti plates and those with untreated polished titanium plates. Moreover, the enhanced gene expression seen in osteoblasts cultured on Ao-Ti plates was canceled following their detachment and transfer to normal culture plates. Our results indicate that ossification of osteoblasts is induced following their direct adherence to a surface of Ao-Ti plates and in response to its properties.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Rho GTPase protein Cdc42 is critical for postnatal cartilage development.2016
Author(s)
Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
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Journal Title
Biochem Biophys Res Commun
Volume: 470
Issue: 4
Pages: 813-817
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cdc42 is critical for cartilage development during endochondral ossification.2015
Author(s)
Suzuki W, Yamada A, Aizawa R, Suzuki D, Kassai H, Harada T, Nakayama M, Nagahama R, Maki K, Takeda S, Yamamoto M, Aiba A, Baba K, Kamijo R
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Journal Title
Endocrinology
Volume: 156
Issue: 1
Pages: 314-322
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effects of antibody to receptor activator of nuclear factor κ-B ligand on inflammation and cartilage degradation in collagen antibody-induced arthritis in mice.2014
Author(s)
Funato S, Matsunaga A, Oh K, Miyamoto Y, Yoshimura K, Tanaka J, Suzuki D, Uyama R, Suzuki H, Mishima K, Nakamura M, Namiki O, Baba K, Inagaki K, Kamijo R.
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Journal Title
J Negat Results Biomed.
Volume: 13
Issue: 1
Pages: 18-18
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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