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Analysis of mechanism of osteoblastic ossification on anodically oxidized titanium plates

Research Project

Project/Area Number 26870583
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

Suzuki Dai  昭和大学, 歯学部, 助教 (00585797)

Research Collaborator SHIBATA Yo  昭和大学, 歯学部 歯科保存学講座 歯科理工学部門, 講師 (30327936)
YAMADA Atsushi  昭和大学, 歯学部 口腔生化学講座, 講師 (50407558)
TAKAMI Masamichi  昭和大学, 歯学部 歯科薬理学講座, 教授 (80307058)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨芽細胞 / 陽極酸化チタン / 石灰化 / 歯科インプラント / 再生歯学
Outline of Final Research Achievements

Our previous results showed enhanced ossification of osteoblasts cultured on anodically oxidized titanium (Ao-Ti) plates. In the present study, we found that the mRNA expression of non-collagenous protein-related genes, which are involved in ossification, in osteoblasts cultured on those plates was increased as compared with those on untreated polished titanium plates. On the other hand, when osteoblasts were cultured in the presence of titanium plates without direct contact there was no significant difference regarding mRNA expression of those genes between culture with Ao-Ti plates and those with untreated polished titanium plates. Moreover, the enhanced gene expression seen in osteoblasts cultured on Ao-Ti plates was canceled following their detachment and transfer to normal culture plates. Our results indicate that ossification of osteoblasts is induced following their direct adherence to a surface of Ao-Ti plates and in response to its properties.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Rho GTPase protein Cdc42 is critical for postnatal cartilage development.2016

    • Author(s)
      Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Issue: 4 Pages: 813-817

    • DOI

      10.1016/j.bbrc.2016.01.111

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Localization and osteoblastic differentiation potential of neural crest-derived cells in oral tissues of adult mice.2015

    • Author(s)
      Ono M
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 464 Issue: 4 Pages: 1209-1214

    • DOI

      10.1016/j.bbrc.2015.07.106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association of aging with gene expression profiling in mouse submandibular glands.2015

    • Author(s)
      Saito Y
    • Journal Title

      Genomics Data

      Volume: 5 Pages: 115-119

    • DOI

      10.1016/j.gdata.2015.05.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Enhanced in vitro biological activity generated by surface characteristics of anodically oxidized titanium ― the contribution of the oxidation effect.2015

    • Author(s)
      Wurihan, Yamada A, Suzuki D, Shibata Y, Kamijo R, Miyazaki T.
    • Journal Title

      European Cells & Materials

      Volume: 29 Pages: 290-302

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cdc42 is critical for cartilage development during endochondral ossification.2015

    • Author(s)
      Suzuki W, Yamada A, Aizawa R, Suzuki D, Kassai H, Harada T, Nakayama M, Nagahama R, Maki K, Takeda S, Yamamoto M, Aiba A, Baba K, Kamijo R
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 1 Pages: 314-322

    • DOI

      10.1210/en.2014-1032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of antibody to receptor activator of nuclear factor κ-B ligand on inflammation and cartilage degradation in collagen antibody-induced arthritis in mice.2014

    • Author(s)
      Funato S, Matsunaga A, Oh K, Miyamoto Y, Yoshimura K, Tanaka J, Suzuki D, Uyama R, Suzuki H, Mishima K, Nakamura M, Namiki O, Baba K, Inagaki K, Kamijo R.
    • Journal Title

      J Negat Results Biomed.

      Volume: 13 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12952-014-0018-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Cdc42 is critical for cartilage development during endochondral ossification at postnatal stage.2015

    • Author(s)
      Nagahama R, Yamada A, Suzuki D, Maki K, Kamijo R.
    • Organizer
      2015 Cell biology ascb annual meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of nephronectin gene expression by 1α, 25-Dyhydroxyvitamin D3.2015

    • Author(s)
      Hiranuma K, Yamada A, Suzuki D, Iijima T, Kamijo R.
    • Organizer
      2015 Cell biology ascb annual meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cdc42は生後成長期の軟骨形成に重要である2015

    • Author(s)
      長濱諒、山田篤、鈴木大、上條竜太郎、槇宏太郎
    • Organizer
      第52回日本口腔組織培養学会学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nephronectinに対する活性型ビタミンD3の発現制御機構の解析2015

    • Author(s)
      平沼克洋、山田篤、鈴木大、飯島毅彦、上條竜太郎
    • Organizer
      第52回日本口腔組織培養学会学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cdc42 in neural crest derived cells is essential for palatal development.2015

    • Author(s)
      Oshima M, Yamada A, Suzuki D, Maki K, Kamijo R.
    • Organizer
      ANZBMS 25th Annual Scientific Meeting
    • Place of Presentation
      Tasmania, Australia
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経堤由来細胞に発現するRhoファミリー低分子量Gタンパク質Cdc42は口蓋形成に必須である2015

    • Author(s)
      大島睦子、山田篤、鈴木大、槇宏太郎、上條竜太郎
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 低分子量Gタンパク質Cdc42は口蓋形成において重要な遺伝子である2015

    • Author(s)
      大島睦子、山田篤、鈴木大、槙宏太郎、上條竜太郎
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟骨形成における恒常活性型Rac1の機能解析2015

    • Author(s)
      鈴木大、Jason Bush、上條 竜太郎、Frank Beier
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Rhoファミリー低分子量Gタンパク質Rac1およびCdc42の骨・軟骨形成における機能解析2015

    • Author(s)
      山田篤、鈴木大、上條竜太郎
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Oncostatin Mによるネフロネクチン発現制御機構の解明2015

    • Author(s)
      黒澤珠希、山田篤、高見正道、鈴木大、守村直子、板部洋之、上條竜太郎
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Cdc42 is essential for cartilage development during endochondral ossification2014

    • Author(s)
      Wataru Suzuki, Atsushi Yamada, Ryo Aizawa, Dai Suzuki, Shu Takeda, Matsuo Yamamoto, Kazuyoshi Baba, Ryutaro Kamijo
    • Organizer
      ANZBMS 24th Annual Scientific Meeting
    • Place of Presentation
      New Zealand
    • Year and Date
      2014-09-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Cdc42は軟骨分化とそれに続く軟骨内骨化に必須である2014

    • Author(s)
      鈴木航、山田篤、相澤怜、鈴木大、竹田秀、山本松男、馬場一美、上條竜太郎
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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