| Project/Area Number |
26870610
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
Biological pharmacy
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| Research Institution | Tokyo Denki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | カスパーゼ / スフィンゴイド塩基 / MAPキナーゼ / 皮膚 / 保湿 / 皮膚保湿 / 角化細胞 / スフィンゴイド |
|---|
| Outline of Final Research Achievements |
We evaluated the mechanism of skin moisture maintaining system involving sphingoid bases. Sub-micromolar doses of sphingoid bases treatment, that doses do not damage cells, were treated on human keratinocyte cells. Caspase-14 mRNA level and protein level was upregulated dose-dependently on HaCaT cells. Furthermore, sphingoid bases-induced caspase-14 was involved of MAPK, especially JNK and p38.
Affecting sphingoid bases to mouse skin resulted in upregulation of caspase-14, presuming that sphingoid bases could maintain skin barrier in vivo.
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