| Project/Area Number |
26870614
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
Shun Nagashima 東京薬科大学, 生命科学部, 助教 (40634465)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | mitochondria / MAM / Alzheimer’s Disease / ミトコンドリア / アルツハイマー病 / 小胞体 / MITOL |
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| Outline of Final Research Achievements |
Mitochondria-associated ER membrane (MAM), the contact site between mitochondria and ER, is closely related with Alzheimer disease because MAM is increased in brain of Alzheimer's disease patients. We previously reported that mitochondrial ubiquitin ligase MITOL regulates MAM formation via Mitofusin2. In this study, we analyzed brain-specific MITOL knockout mice in order to elucidate MAM functions in brain. Moreover, we also generated MITOL-deficient Alzheimer's disease mouse models so that we studied the roles of MAM in Alzheimer's disease.
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