| Project/Area Number |
26870625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
Neurophysiology / General neuroscience
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
Kabayama Miyuki 日本獣医生命科学大学, 獣医学部, 助教 (70415115)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 情動行動 / モノアミンオキシダーゼ / ユビキチンリガーゼ / モノアミン |
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| Outline of Final Research Achievements |
Monoamine oxidase A (MAO-A), the catabolic enzyme of monoamine transmitters, plays a critical role in emotional and social behavior. MAO-A has long been considered to be a central factor at the interface of psychiatry and pharmacology. We previously reported that E3 ubiquitin ligase Rines regulates brain MAO-A protein levels, monoamine levels and emotional and social behavior. In this study, we investigate how Rines regulates MAO-A protein levels and monoamine levels in emotional and social behavior using juvenile~aged Rines KO mice. Here we found that Rines regulates monoaminergic dynamics and emotional behavior in age-dependent manner.
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