The functional analysis of A. naeslundii fimbriae in periodontal diseases

• Project/Area Number: 26870665
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology; Morphological basic dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: SATO TAKENORI 神奈川歯科大学, 歯学研究科(研究院), 研究員 (40638904)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯周炎 / バイオフィルム / A.naeslundii / 線毛 / 遺伝子

Outline of Final Research Achievements

The purpose of this study was analyzed the genes of A. naeslundii fimbriae, and evaluated the biofilm removal of a titanium oxide semiconductor with an electric toothbrush. In these results, we couldn’t succeed in the mutation of A. naeslundii fimbriae, but titanium oxide photocatalytic properties and electric current contribute to the reduction of oral biofilm and aid in the prevention of periodontal diseases.

Research Products

• [Journal Article] Actinomyces naeslundii の歯槽骨吸収機構解明と歯周病予防法の探索 (2015)
  • Author(s): 佐藤武則，佐々木 悠，渡辺清子，浜田信城
  • Journal Title: 神奈川歯学 Volume: 50 Pages: 89-93
  • Peer Reviewed
• [Journal Article] 文献と臨床の橋わたし 口腔細菌から読み取る歯周治療のエビデンス(第1回) 口腔細菌が形成するバイオフィルムとは? (2015)
  • Author(s): 佐藤武則，佐々木 悠，浜田信城
  • Journal Title: 日本歯科評論 Volume: 75 Pages: 145-148
  • NAID: 40020597992
• [Journal Article] 文献と臨床の橋わたし 口腔細菌から読み取る歯周治療のエビデンス(第2回) バイオフィルム除去に効果的な抗菌療法とは? (2015)
  • Author(s): 佐々木 悠，佐藤武則，浜田信城
  • Journal Title: 日本歯科評論 Volume: 75 Pages: 143-146
  • NAID: 40020627818
• [Journal Article] 文献と臨床の橋わたし 口腔細菌から読み取る歯周治療のエビデンス(第3回) インプラント周囲炎の原因と対応とは? (2015)
  • Author(s): 佐藤武則，佐々木 悠，浜田信城
  • Journal Title: 日本歯科評論 Volume: 75 Pages: 139-142
• [Journal Article] Efficacy of a solar-powered TiO2 semiconductor electric toothbrush on P. gingivalis biofilm (2015)
  • Author(s): Sato T, Hirai N, Oishi Y, Uswak G, Komiyama K, Hamada N
  • Journal Title: Am J Dent Volume: 28 Pages: 81-84
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis-induced alveolar bone loss is accelerated in the stroke-prone spontaneously hypertensive rat. (2015)
  • Author(s): Tokutomi F, Wada-Takahashi S, Sugiyama S, Toyama T, Sato T, Hamada N, Tsukinoki K, Takahashi SS, Lee MC
  • Journal Title: Arch Oral Biol Volume: 60 Issue: 6 Pages: 911-918
  • DOI: 10.1016/j.archoralbio.2015.02.012
  • Peer Reviewed / Open Access
• [Journal Article] Ameliorating effects of Juzentaihoto on restraint stress and P. gingivalis-induced alveolar bone loss. (2014)
  • Author(s): Takeda O, Toyama T, Watanabe K, Sato T, Sasaguri K, Akimoto S, Sato S, Kawata T, Hamada N
  • Journal Title: Arch Oral Bio Volume: 59 Issue: 11 Pages: 1130-1138
  • DOI: 10.1016/j.archoralbio.2014.06.010
  • Peer Reviewed / Open Access
• [Journal Article] 重曹を添加した電解次亜塩素酸水の Streptococcus mutansに対する殺菌効果およびバイオフィルム除去効果 (2014)
  • Author(s): 井上吉登, 佐藤 武則, 藤田茉依子, 大久保孝一郎, 熊田秀文, 浜田信城, 木本茂成
  • Journal Title: 神奈川歯学 Volume: 49 Pages: 111-118
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Porphyromonas gingivalis lipid A の合成戦略 ―光学活性beta-ヒドロキシ脂肪酸の新規光学分割法― (2014)
  • Author(s): 熊田秀文, 佐藤武則, 遠藤 生, 藤岡 隼, 築山光一, 浜田信城, 藤本賢二
  • Journal Title: 神奈川歯学 Volume: 49 Pages: 134-140
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Efficacy of a toothpaste containing natural ingredient against oral bacteria (2015)
  • Author(s): Sato T, Hamada N
  • Organizer: The 93rd General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Boston, USA.
  • Year and Date: 2015-03-10 – 2015-03-15
• [Presentation] Efficacy of a solar-powered TiO2 semiconductor electric toothbrush (2014)
  • Author(s): Sato T, Oishi Y, Hamada N
  • Organizer: The 7th World Congress on Preventive and Regenerative Medicine
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-11-04 – 2014-11-08
• [Presentation] 歯磨剤の抗菌効果および歯槽骨吸収抑制効果の検討 (2014)
  • Author(s): 佐藤武則, 早坂奈美, 遠山 歳三, 高橋 俊介, 浜田 信城
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Antimicrobial activity and inhibitory effect of alveolar bone resorption by a toothpaste containing Pycnogenol®. (2014)
  • Author(s): Sato T, Toyama T, Takahashi SS, Hamada N
  • Organizer: International Union of Microbiological Societies 2014
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2014-07-26 – 2014-08-01
• [Presentation] 太陽電池内蔵電動歯ブラシの酸化チタン光触媒作用によるバイオフィルム除去効果 (2014)
  • Author(s): 佐藤武則, 渡辺清子, 浜田信城
  • Organizer: 医学生物学電子顕微鏡技術学会第30回学術講演会および総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-23 – 2014-05-25