• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulations of Hepatic and pancreatic autonomic nerves by leptin and application to improvement of glucose metabolism

Research Project

Project/Area Number 26870672
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Metabolomics
Research InstitutionKanazawa Medical University

Principal Investigator

TANIDA Mamoru  金沢医科大学, 医学部, 講師 (70512309)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords自律神経 / レプチン / 糖代謝 / 肝臓 / 視床下部 / 細胞内シグナル伝達 / 糖尿病 / 血糖調節 / 遺伝子組換えマウス
Outline of Final Research Achievements

Diabetes mellitus is one of serious health problem. In this experiment, we used animals and examined effects of leptin, appetite suppressor, on autonomic nerves to the liver and the pancreas which play an important role in regulating glucose metabolism, and cleared possible role of leptin in diabetes therapy. We showed that leptin stimulated liver autonomic nerves through the hypothalamic molecular signals. Thus, our evidence suggest that leptin may be useful reagent for diabetes treatment via the brain.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (23 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 23 results,  Acknowledgement Compliant: 1 results,  Open Access: 6 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] アイオワ大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice.2016

    • Author(s)
      Wang M, Shibamoto T, Kuda Y, Tanida M, Zhang T, Song J, Kurata Y.
    • Journal Title

      Life Sciences

      Volume: 147 Pages: 77-84

    • DOI

      10.1016/j.lfs.2016.01.034

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways.2016

    • Author(s)
      Yamamoto, N., Fujii, Y., Kasahara, R., Tania, M., Ohora, K., Ono, Y., Suzuki, K. and Sobue, K.
    • Journal Title

      Glia

      Volume: 64 Issue: 6 Pages: 952-962

    • DOI

      10.1002/glia.22974

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016

    • Author(s)
      Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
    • Journal Title

      Cell reports

      Volume: 14 Issue: 10 Pages: 2362-2374

    • DOI

      10.1016/j.celrep.2016.02.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intragastric injection of Lactobacillus casei strain Shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor or peripheral 2-deoxy-d-glucose in anesthetized rats.2016

    • Author(s)
      Tanida M, Takada M, Kato-Kataoka A, Kawai M, Miyazaki K, Shibamoto T.
    • Journal Title

      Neuroscience Letters

      Volume: 619 Pages: 114-120

    • DOI

      10.1016/j.neulet.2016.03.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats2016

    • Author(s)
      Wang M, Shibamoto T, Kuda Y, Tanida M, Zhang T, Song J, Mukai K, Kurata Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 4 Pages: 556-563

    • DOI

      10.1248/bpb.b15-00864

    • NAID

      130005141682

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Role of Lumbar Sympathetic Nerves in Regulation of Blood Flow to Skeletal Muscle during Anaphylactic Hypotension in Anesthetized Rats.2016

    • Author(s)
      Song J, Tanida M, Shibamoto T, Zhang T, Wang M, Kuda Y, Kurata Y
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0150882-e0150882

    • DOI

      10.1371/journal.pone.0150882

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).2015

    • Author(s)
      hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
    • Journal Title

      Neuroscience

      Volume: 297 Pages: 95-104

    • DOI

      10.1016/j.neuroscience.2015.03.062

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats.2015

    • Author(s)
      Konishi Y, Koosaka Y, Maruyama R, Imanishi K, Kasahara K, Matsuda A, Akiduki S, Hishida Y, Kurata Y, Shibamoto T, Satomi J, Tanida M.
    • Journal Title

      Brain Research Bulletin

      Volume: 111 Pages: 48-52

    • DOI

      10.1016/j.brainresbull.2014.11.004

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible role of afferent autonomic signals in abdominal organs in anorexic and cardiovascular responses to nicotine injection in rats.2015

    • Author(s)
      Yagi S, Tanida M, Satomi J.
    • Journal Title

      Neuroreport

      Volume: 26 Issue: 8 Pages: 445-449

    • DOI

      10.1097/wnr.0000000000000361

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice2015

    • Author(s)
      Wang M, Shibamoto T, Shinomiya S, Yamamoto Y, Kurata Y, Kuda Y, Tanida M, Toga H
    • Journal Title

      Journal of Cardiovascular Pharmacology

      Volume: 65 Issue: 4 Pages: 325-334

    • DOI

      10.1097/fjc.0000000000000199

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats.2015

    • Author(s)
      Wang M, Shibamoto T, Kuda Y, Tanida M, Kurata Y.
    • Journal Title

      Experimental Lung Research

      Volume: 41 Issue: 6 Pages: 324-334

    • DOI

      10.3109/01902148.2015.1032448

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.2015

    • Author(s)
      Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K.
    • Journal Title

      The Journal of Neuroscience

      Volume: 35 Pages: 474-484

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hypothalamic Nesfatin-1 Stimulates Sympathetic Nerve Activity via Hypothalamic ERK Signaling.2015

    • Author(s)
      Tanida, M., Gotoh, H., Yamamoto, N., Wang, M., Kuda, Y., Kurata, Y., Mori, M., Shibamoto, T.
    • Journal Title

      Diabetes

      Volume: 64 Issue: 11 Pages: 3725-3736

    • DOI

      10.2337/db15-0282

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of afferent autonomic signals in abdominal organs in anorexic and cardiovascular responses to nicotine injection in rats.2015

    • Author(s)
      Yagi S, Tanida M, Satomi J
    • Journal Title

      Neuroreport

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.2015

    • Author(s)
      Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K.
    • Journal Title

      J Neurosci.

      Volume: 35 Issue: 2 Pages: 4747-484

    • DOI

      10.1523/jneurosci.1828-14.2015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of anesthetics on the renal sympathetic response to anaphylactic hypotension in rats.2014

    • Author(s)
      Sun L, Tanida M, Wang M, Kuda Y, Kurata Y, Shibamoto T.
    • Journal Title

      Plos One

      Volume: 9 Issue: 11 Pages: e113945-e113945

    • DOI

      10.1371/journal.pone.0113945

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine.2014

    • Author(s)
      Wang M, Shibamoto T, Tanida M, Kuda Y, Kurata Y.
    • Journal Title

      Life Sciences

      Volume: 116 Issue: 2 Pages: 98-105

    • DOI

      10.1016/j.lfs.2014.09.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.2014

    • Author(s)
      Yamamoto N, Tanida M, Kasahara R, Sobue K, Suzuki K
    • Journal Title

      J Neurochem

      Volume: 131 Issue: 3 Pages: 323-32

    • DOI

      10.1111/jnc.12828

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Olfactory stimulatory with grapefruit and lavender oils change autonomic nerve activity and physiological function.2014

    • Author(s)
      Nagai K, Niijima A, Horii Y, Shen J, Tanida M.
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 185 Pages: 29-35

    • DOI

      10.1016/j.autneu.2014.06.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Injection of Lactobacillus casei strain Shirota affects autonomic nerve activities in a tissue-specific manner, and regulates glucose and lipid metabolism in rats.2014

    • Author(s)
      Tanida M, Imanishi K, Akashi H, Kurata Y, Chonan O, Naito E, Kunihiro S, Kawai M, Kato-Kataoka A, Shibamoto T.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 5 Issue: 2 Pages: 153-161

    • DOI

      10.1111/jdi.12141

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II and vasopressin are involved in the defense system against anaphylactic hypotension in anesthetized rats.2014

    • Author(s)
      Wang M, Shibamoto T, Kuda Y, Sun L, Tanida M, Kurata Y.
    • Journal Title

      Eur J Pharmacol.

      Volume: 731 Pages: 38-43

    • DOI

      10.1016/j.ejphar.2014.03.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soy isoflavone affects the autonomic nervous system in a tissue-specific manner in anesthetized rats2014

    • Author(s)
      Tanida M, Imanishi K, Komatsu M, Satomi J, Yamamoto N, Wang M, Kurata Y, Shibamoto T.
    • Journal Title

      Experimental Biology and Medicine

      Volume: 239 Issue: 4 Pages: 477-483

    • DOI

      10.1177/1535370213519197

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes.2014

    • Author(s)
      Yamamoto N,Tanida M,Ono Y,Kasahara R,Fujii Y,Ohora K,Suzuki K,Sobue K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 445 Issue: 1 Pages: 214-7

    • DOI

      10.1016/j.bbrc.2014.01.168

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 摂食調節因子 nesfatin-1 による自律神経を介する循環調節機構2016

    • Author(s)
      谷田 守
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] レプチンによる肝臓自律神経調節における視床下部弓状核の役割2015

    • Author(s)
      谷田 守、芝本 利重
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] GLP1脳室内投与によるマウス自律神経調節と高脂肪食性肥満マウスへの作用2015

    • Author(s)
      谷田 守、九田裕一、倉田康孝、芝本利重
    • Organizer
      第25回日本病態生理学会大会
    • Place of Presentation
      愛媛大学(愛媛県・松山市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルコール投与がアナフィラキシー低血圧時の腎臓交感神経活動へ及ぼす影響2015

    • Author(s)
      谷田 守、王 墨飛、宋 潔、九田 裕一、倉田 康孝、芝本 利重
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      ウインクあいち(愛知県・名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] アナフィラキシー低血圧時の血圧と腎臓交感神経応答に対するアルコール投与の影響2015

    • Author(s)
      谷田 守、芝本 利重
    • Organizer
      第30回日本Shock学会総会
    • Place of Presentation
      京王プラザホテル八王子(東京都・八王子市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] GLP-1によるマウス自律神経調節の視床下部分子メカニズム2015

    • Author(s)
      谷田守、九田裕一、倉田康孝、芝本利重
    • Organizer
      第92回日本生理学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] GLP-1のマウス脳室内投与による交感神経系促進の細胞内シグナリング2014

    • Author(s)
      谷田守、芝本利重
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ラットアナフィラキシーショックにおける腎臓交感神経活動の反応と麻酔薬の影響2014

    • Author(s)
      谷田守、孫玲玲、芝本利重
    • Organizer
      第24回日本病態生理学会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2014-08-08 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] アナフィラキシーショクにおけるラット腎臓交感神経活動の反応と麻酔薬の影響2014

    • Author(s)
      谷田守
    • Organizer
      第29回日本Shock学会総会
    • Place of Presentation
      松山市コミュニティーセンター(愛媛県松山市)
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Book] Imidazole Dipeptides: Food and Nutritional Components in Focus No. 8Carnosine and the control of blood glucose2015

    • Author(s)
      Okumura N, Tanida M, Niijima A, Tsuruoka N, Kiso Y, Nagai K
    • Total Pages
      19
    • Publisher
      Royal Society of Chemistry
    • Related Report
      2014 Research-status Report
  • [Remarks] 金沢医科大学 生理学2講座

    • URL

      http://medicine-physiol2.kanazawa-med.labos.ac/one/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi