| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Nonalcoholic steatohepatitis (NASH) is one of lifestyle-related diseases drawing more attention in recent years and develops in patients with diabetes and/or dyslipidemia based on obesity. Molecular hydrogen has been shown to exhibit anti-inflammatory effect as well as an antioxidative effect. Therefore, we investigated whether the progression of liver cancer in NASH model mice can be suppressed by molecular hydrogen. We found that molecular hydrogen controls second hit of inflammation and oxidative stress leading to the onset of NASH, as well as protecting the mitochondria by modifying gene expression by influencing the epigenetic mechanism of histone methylation modification, simultaneously inducing mtUPR.
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