Genetic/epigenetic interaction in the gastric carcinogenesis

• Project/Area Number: 26870685
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Gastroenterology
• Research Institution: Fujita Health University
• Principal Investigator: Tahara Tomomitsu 藤田保健衛生大学, 医学部, 講師 (80533968)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 胃癌 / 遺伝子変異 / 遺伝子メチル化 / 分子サブタイプ / 除菌 / epigenetics / genetics

Outline of Final Research Achievements

To clarify the role of genetic/epigenetic interaction in the gastric carcinogenesis, we investigated genetic/epigenetic anomalies of primary gastric cancer, adjacent gastric mucosa and non-neoplastic gastric mucosa from cancer-free, but H. pylori positive patients, who are at risk for developing gastric cancer. We showed that molecular subtypes, combining genetic/epigenetic anomalies is associated with prognosis of gastric cancer patients. We also showed that DNA methylation status in the non-neoplastic gastric mucosa is associated with its morphologic features.

Research Products

• [Journal Article] Magnifying narrow-band imaging of gastric mucosal morphology predicts the H. pylori-related epigenetic field defect. (2017)
  • Author(s): Tahara T, Yamazaki J, Tahara S, Okubo M, Kawamura T, Horiguchi N, Ishizuka T, Nagasaka M, Nakagawa Y, Shibata T, Kuroda M, Ohmiya N.
  • Journal Title: Sci Rep. Sci Rep. Volume: 7 Issue: 1 Pages: 3090-3090
  • DOI: 10.1038/s41598-017-03294-8
  • Peer Reviewed / Open Access
• [Journal Article] Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer. (2016)
  • Author(s): Tahara T, Shibata T, Okamoto Y, Yamazaki J, Kawamura T, Horiguchi N, Okubo M, Nakano N, Ishizuka T, Nagasaka M, Nakagawa Y, Ohmiya N
  • Journal Title: Oncotarget Volume: 7 Issue: 27 Pages: 42252-42260
  • DOI: 10.18632/oncotarget.9770
  • Peer Reviewed / Open Access
• [Journal Article] Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa. (2016)
  • Author(s): Tahara T, Shibata T, Okubo M, Kawamura T, Horiguchi N, Ishizuka T, Nakano N, Nagasaka M, Nakagawa Y, Ohmiya N.
  • Journal Title: Oncotarget Volume: 7 Issue: 28 Pages: 43989-43996
  • DOI: 10.18632/oncotarget.9764
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Potential utility of DNA methytlation as a biomarker for prediction of ulcerative colitis associated colitic cancer (UCAC). (2015)
  • Author(s): Tomomitsu Tahara, Naoko Nakano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Naoki Ohmiya, Ichiro Hirata.
  • Organizer: AACR Annual Meeting 2015.
  • Place of Presentation: Pennsylvania Convention Center Philadelphia, Pennsylvania.
  • Year and Date: 2015-04-18
• [Presentation] Endoscopic, Clinic-Pathological and Molecular Features of Epstein-Barr Virus (EB) Positive Gastric Carcinoma (2014)
  • Author(s): Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, et al.
  • Organizer: Digestive Disease Week (DDW) 2014
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2014-05-03 – 2014-05-06