Genetic/epigenetic interaction in the gastric carcinogenesis
Project/Area Number |
26870685
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
Gastroenterology
|
Research Institution | Fujita Health University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 胃癌 / 遺伝子変異 / 遺伝子メチル化 / 分子サブタイプ / 除菌 / epigenetics / genetics |
Outline of Final Research Achievements |
To clarify the role of genetic/epigenetic interaction in the gastric carcinogenesis, we investigated genetic/epigenetic anomalies of primary gastric cancer, adjacent gastric mucosa and non-neoplastic gastric mucosa from cancer-free, but H. pylori positive patients, who are at risk for developing gastric cancer. We showed that molecular subtypes, combining genetic/epigenetic anomalies is associated with prognosis of gastric cancer patients. We also showed that DNA methylation status in the non-neoplastic gastric mucosa is associated with its morphologic features.
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Report
(5 results)
Research Products
(5 results)
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[Journal Article] Magnifying narrow-band imaging of gastric mucosal morphology predicts the H. pylori-related epigenetic field defect.2017
Author(s)
Tahara T, Yamazaki J, Tahara S, Okubo M, Kawamura T, Horiguchi N, Ishizuka T, Nagasaka M, Nakagawa Y, Shibata T, Kuroda M, Ohmiya N.
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Journal Title
Sci Rep. Sci Rep.
Volume: 7
Issue: 1
Pages: 3090-3090
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer.2016
Author(s)
Tahara T, Shibata T, Okamoto Y, Yamazaki J, Kawamura T, Horiguchi N, Okubo M, Nakano N, Ishizuka T, Nagasaka M, Nakagawa Y, Ohmiya N
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Journal Title
Oncotarget
Volume: 7
Issue: 27
Pages: 42252-42260
DOI
Related Report
Peer Reviewed / Open Access
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