New treatment strategy against skeletal muscle atrophy using combination of stretching and heat stimulation for patients on steroid
| Project/Area Number |
26870691
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
Rehabilitation science/Welfare engineering
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| Research Institution | Nihon Fukushi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ステロイド / 筋萎縮 / 熱刺激 / ストレッチ / 骨格筋 / タンパク質合成 / タンパク質分解 / heat shock protein |
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| Outline of Final Research Achievements |
This study aimed to investigate the effects of combination of stretching and heat stimulation on the steroid-induced muscle atrophy in vitro and vivo. The results demonstrate that heat stimulation can prevent the progression of skeletal muscle atrophy, and this effect is linked to the modulation of both catabolic and anabolic signaling pathways. The study also suggests that stretching induce skeletal muscle hypertrophy, possibly through the activation of anabolic signaling pathways. Hence, the combination of the heat stimulation and stretching may be effective in steroid-induced muscle atrophy.
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Report
(4 results)
Research Products
(20 results)
