Novel insights into the expression and function of heat shock protein Hsp105 in tumor tissues and cells
| Project/Area Number |
26870701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
SAITO YOUHEI 京都薬科大学, 薬学部, 助教 (90411032)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 熱ショックタンパク質 / 腫瘍マーカー / 核内発現 / Hsp105 / Hsp70 / Stat3 / HIF-1 |
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| Outline of Final Research Achievements |
We focused and analyzed the expression and localization of Hsp105 in tumor tissues. Immunohistochemical analysis revealed the overexpression of Hsp105 in nucleus of some tumor tissues. The findings using cell lines indicated the possibility that Hsp105 localizes in the nucleus and affects the expression and activation of anti-cancer target proteins. Although further studies are needed, these observations will provide novel strategy for the Hsp105-targeted anti-cancer therapy and diagnosis.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Yeast two-hybrid and one-hybrid screenings identify regulators of hsp70 gene expression2016
Author(s)
Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, Takamori M, Yamagishi N, Kuga T, Hatayama T, Nakayama Y.
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Journal Title
Journal of Cellular Biochemistry.
Volume: in press
Issue: 9
Pages: 2109-2117
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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