Investigation of the role of intracellular CO using a supramolecular heme protein model complex showing high CO affinity
Project/Area Number |
26870704
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Chemical biology
Bio-related chemistry
|
Research Institution | Doshisha University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 内因性一酸化炭素 / ポルフィリン / シクロデキストリン / ヘムタンパク質 / 超分子化学 / 一酸化炭素 / ガスバイオロジー / 生理機能 / 超分子 |
Outline of Final Research Achievements |
Carbon monoxide (CO), a well known toxic gas, is continuously produced in the living body. Although the endogenous CO is considered to function in the biological system, the role of CO in biology has not been fully understood. Here, to investigate the biological function of endogenous CO, we utilized a supramolecular heme protein model complex, hemoCD, to remove endogenous CO from the living organisms. HemoCD was capable of quantitatively removing endogenous CO in the mice body due to its extremely high CO affinity. As a result, we succeeded to completely remove CO from the mice body, in which we found a biological feedback mechanism of endogenous CO to compensate the lack of Co in the living organisms (J. Am. Chem. Soc. 2016, 138, 5417-5425).
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Report
(3 results)
Research Products
(10 results)