| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Carbon monoxide (CO), a well known toxic gas, is continuously produced in the living body. Although the endogenous CO is considered to function in the biological system, the role of CO in biology has not been fully understood. Here, to investigate the biological function of endogenous CO, we utilized a supramolecular heme protein model complex, hemoCD, to remove endogenous CO from the living organisms. HemoCD was capable of quantitatively removing endogenous CO in the mice body due to its extremely high CO affinity. As a result, we succeeded to completely remove CO from the mice body, in which we found a biological feedback mechanism of endogenous CO to compensate the lack of Co in the living organisms (J. Am. Chem. Soc. 2016, 138, 5417-5425).
|
