| Project/Area Number |
26870721
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Cardiovascular surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
NEMOTO Shintaro 大阪医科大学, 医学部, 教授 (20237811)
KISHI Kanta 大阪医科大学, 医学部, 助教 (20408503)
MOTOHASHI Yoshikazu 大阪医科大学, 医学部, 助教 (80764993)
DAN Kazunori 株式会社東海メディカルプロダクツ
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 先天性心疾患 / チアノーゼ性心疾患 / 姑息手術 / 小口径人工血管 / 肺血流 / 心不全 / 流量調整 / Blalock-Taussig shunt / ブラロック短絡術 |
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| Outline of Final Research Achievements |
A small vascular graft has been used in Blalock-Taussig shunt (BTS) operation, a cornerstone palliative surgery to increase pulmonary blood flow for cyanotic congenital heart disease. There are no standardized criteria for selection of the graft size because of a wide variety of cardiac anomalies and size of patients. Either excess or insufficient blood flow may account for mortality and severe morbidity after the surgery. We developed a simple device consisting of a specially designed balloon to optimize the graft flow to prevent the adverse events. The device provided good flow control by inflating and deflating the balloon in both ex vivo analysis using a simulation circuit model and in vivo analysis using a canine model of replacement of the right carotid artery with a small graft wrapped with the device. The effect on flow regulation sustained up to three months in the animal model. This simple device could improve postoperative outcome in the clinical setting of BTS.
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