| Project/Area Number |
26870757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Biological pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マスト細胞 / IgE / 分化 / TNF-alpha |
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| Outline of Final Research Achievements |
I established a new primary mast cells; high-dose IgE treated mast cells (HIMCs) to study the effects of IgE on differentiation and functions. Using HIMCs, I identified that IgE has a critical role of mast cell differentiation and functions. To site a case, LPS-induced cytokine production are markedly reduced in HIMCs.
Interestingly, only a modest of amino acid sequence of antigen binding site changes mast cell properties. I proposed that to better understand IgE effects on mast cell differentiation and functions,how important it is that not only levels but olso profiles.
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