The developement for effectiveness of rehabilitation in obstructive sleep apnea

• Project/Area Number: 26870760
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical nursing; Rehabilitation science/Welfare engineering
• Research Institution: Himeji Dokkyo University
• Principal Investigator: Kanezaki Masashi 姫路獨協大学, 医療保健学部, 講師 (10707871)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 閉塞型睡眠時無呼吸 / オトガイ舌筋 / 舌前方突出筋力 / 睡眠

Outline of Final Research Achievements

Although tongue protrusion strength by genioglossus activity during sleep contributes to the maintenance of airway patency in patients with OSA, the relationship between tongue protrusion strength in the arousal state and obstructive sleep apnea has not been fully elucidated. We investigated relationships between the tongue protrusion strength and polysomnographic findings. We enrolled twenty normal subjects and 26 subjects with OSA. All subjects completed the measurement of tongue protrusion strength. Each subject with OSA was evaluated by full polysomnography. The degree of tongue protrusion strength was assessed by maximum voluntary contraction against the tongue depressor connected with a strain gauge dynamometer. The tongue protrusion strength was negatively correlated with obstructive apnea time, apnea index (AI) and the percent of sleep stage 2. Tongue protrusion strength measured in the arousal state is predictive of the airway patency during sleep in OSA.

Research Products

• [Journal Article] Tongue Protrusion Strength in Arousal State Is Predictive of the Airway Patency in Obstructive Sleep Apnea (2015)
  • Author(s): Kanezaki M, Ogawa T, Izumi T.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 236 Issue: 4 Pages: 241-245
  • DOI: 10.1620/tjem.236.241
  • NAID: 130005083527
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distractive Auditory Stimuli Alleviate the Perception of Dyspnea Induced by Low-Intensity Exercise in Elderly Subjects With COPD. (2015)
  • Author(s): Shingai K, Kanezaki M, Senjyu H.
  • Journal Title: Respiratory Care Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 舌前方突出筋力と閉塞型睡眠時無呼吸 (2015)
  • Author(s): 金崎雅史 、小川晃弘 、泉唯史
  • Organizer: 第25回日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート
  • Year and Date: 2015-10-15
• [Presentation] Olfactory stimulation of TRPM8 agonist lessen the perception of dyspnea induced by constant load exercise in never-smoker (2015)
  • Author(s): Kanezaki M.
  • Organizer: European Respiraotry Society International Congress 2015 in Amsterdam
  • Place of Presentation: Amsterdam RAI
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Effect of olfactory stimulation of TRPM8 agonist on perception of dyspnea induced by constant load exercise in healthy never-smokers. TRPM8 agonist on exercise-induced dyspnea. (2015)
  • Author(s): M. Kanezaki
  • Organizer: 第50回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-05 – 2015-06-07
• [Presentation] Effect of olfactory stimulation of TRPM8 agonist on perception of dyspnea induced by constant load exercise in healthy never-smokers.TRPM8 agonist on exercise-induced dyspnea (2015)
  • Author(s): Kanezaki M
  • Organizer: 第50回日本理学療法学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2015-06-05
• [Presentation] IP患者におけるBreath‐holding testを用いた新たな呼吸困難感評価法の開発 (2014)
  • Author(s): 新貝和也，金崎雅史，小川智也，渡邉文子，平澤純，田中裕子，三嶋卓也，古川拓朗，長江優介，谷口博之
  • Organizer: 第24回呼吸ケアリハビリテーション学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] The strength of genioglossus in the arousal state contributes the airway patency in patients with OSAS (2014)
  • Author(s): M. Kanezaki, A. Ogawa, A. Masaki
  • Organizer: European Respiratory Society International Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] 覚醒時オトガイ舌筋筋力と睡眠呼吸障害との関連についての検討 (2014)
  • Author(s): 金崎 雅史、小川 晃弘、泉 唯史
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] COPD患者におけるBreath-holding testによる新たな呼吸困難感評価法の開発 (2014)
  • Author(s): 新貝和也, 金崎雅史, 岡本一紀, 谷口博之, 小川智也, 渡邉文子, 平澤純, 三嶋卓也, 田中裕子, 古川拓朗, 長江優介, 津田徹
  • Organizer: 第49回日本理学療法学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-30 – 2014-06-01