| Project/Area Number |
26870765
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Cardiovascular medicine
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| Research Institution | National Center for Geriatrics and Gerontology (2015-2016)
Kawasaki Medical School (2014) |
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Principal Investigator |
SAJI Naoki 国立研究開発法人国立長寿医療研究センター, もの忘れセンター, 副センター長 (30624910)
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| Research Collaborator |
TONE Shigenobu 東京電機大学, 理工学部生命理工学系分子発生生物学研究室, 教授 (70211399)
SAKURAI Takashi 国立研究開発法人国立長寿医療研究センター, もの忘れセンター, センター長 (50335444)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳小血管病 / 脳梗塞 / バイオマーカー / 脈波 / 脈波伝播速度 / 脳卒中 / 血管内皮機能障害 |
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| Outline of Final Research Achievements |
Increase of pulse wave velocity (PWV) detriments blood vessels and can cause cerebrovascular, cardiovascular diseases. The aim of this study is to clarify the association between PWV and blood vessel function in patients with cerebrovascular diseases. We assessed patient’s clinical features, PWV, and blood biomarkers such as high sensitivity C-reactive protein, interleukin-6, and matrix metalloproteinase-9. We found that patient’s clinical features and outcomes are associated with PWV and biomarkers. These findings may contribute to predict patient’s outcome and to develop new treatment for stroke.
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