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Parenting and prefrontal development in humans- Chimpanzees, macaques, marmosets as experimental models

Research Project

Project/Area Number 26870827
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Physical anthropology
Research InstitutionKeio University (2015-2016)
Central Institute for Experimental Animals (2014)

Principal Investigator

Tomoko Sakai  慶應義塾大学, 医学部(信濃町), 訪問研究員 (30640099)

Research Collaborator OKANO Hideyuki  
SASAKAI Erika  
OKANO James Hirotaka  
MIKAMI Akichika  
MATSUI Mie  
HAMADA Yuzuru  
MORI Susumu  
OISHI Kenichi  
HATA Junichi  
OHTA Hiroki  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳進化 / 脳発達 / 前頭前野 / マーモセット / チンパンジー / ヒト / MRI / 霊長類
Outline of Final Research Achievements

In this study, using magnetic resonance imaging (MRI), I tracked the developmental patterns of the brain structures during infancy and the juvenile stage in common marmosets, chimpanzees, and humans. Through a comparison of the brain development among three primates, we clarified common features in marmosets, chimpanzee, and humans (primate -shared features), common features in chimpanzees and humans (hominoid-shared features), common features in marmosets and humans (allomothering-shared features), marmoset-specific features, chimpanzee-specific features, and human-specific features.
As main research results of this study, I wrote two peer-reviewed papers (Sakai et al., Neuroscience Research, 2017; Sakai et al., PLOSONE, peer-reviewed), 2 books and conducted the presentations in the meeting and symposiums as 4 invited lectures. Moreover, in 2015, I received the excellent oral presentation award by the 60th Primates Workshop.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (2 results) Remarks (8 results)

  • [Int'l Joint Research] Department of Radiology/Johns Hopkins University/School of Medicine(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Department of Radiology/Johns Hopkins University/School of Medicine(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Elucidation of developmental patterns of marmoset corpus callosum through a comparative MRI in marmosets, chimpanzees, and humans2017

    • Author(s)
      Tomoko Sakai, Yuji Komaki, Junichi Hata, Junko Okahara, Norio Okahara, Takashi Inoue, Akichika Mikami, Mie Matsui, Kenichi Oishi, Erika Sasaki, and Hideyuki Okano
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 25-34

    • DOI

      10.1016/j.neures.2017.04.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Developmental changes in the corpus callosum from infancy to early adulthood: A structural magnetic resonance imaging study.2015

    • Author(s)
      Tanaka-Arakawa MM, Matsui M, et al
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 1-13

    • DOI

      10.1371/journal.pone.0118760

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 計算解剖学的手法によるヒト特異的な脳構造の進化基盤の解明2017

    • Author(s)
      酒井朋子
    • Organizer
      日本学術振興会日本人研究者交流会 2016年度冬
    • Place of Presentation
      カルフォルニア(アメリカ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mapping Evolution and Development of the Primate Brain by Neuroimaging Techniques2016

    • Author(s)
      Tomoko Sakai
    • Organizer
      文部科学省平成27年度科学技術人材育成費補助事業「ダイバーシティ研究環境実現イニシアティブ(特色型)」 国際シンポジウム“How Human Evolved Supersize Brains-The Growth of the Brain-”
    • Place of Presentation
      富山大学(富山県富山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 高磁場MRIによる霊長類の脳神経回路構造の比較研究2016

    • Author(s)
      酒井朋子,畑純一,太田裕貴,小川優樹,新宅勇太,大石健一,森進,岡野ジェイムズ洋尚,濱田穣,岡野栄之
    • Organizer
      第60回プリマーテス研究会
    • Place of Presentation
      日本モンキーセンター(愛知県犬山市)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Comparing the development of the corpus callosum in infant and juvenile chimpanzees and humans2016

    • Author(s)
      Tomoko Sakai
    • Organizer
      19th Annual MR Division Retreat, Johns Hopkins University School of Medicine
    • Place of Presentation
      ペンシルベニア(アメリカ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトの大脳化の由来:霊長類の脳の進化・発達の観点から2015

    • Author(s)
      酒井朋子
    • Organizer
      富山大学大学院医学薬学研究部(医学)生命融合科学教育部大学院セミナー
    • Place of Presentation
      富山大学(富山県富山市)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Developmental patterns of the corpus callosum in common marmosets, chimpanzees, and humans2015

    • Author(s)
      Sakai, T., Komaki, Y., Hata, J., Mikami, A., Matsui, M., Okahara, J., Okahara, N., Inoue, T., Erika Sasaki, E., and Okano, H.
    • Organizer
      The 38nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Developmental patterns of the corpus callosum in common marmosets, chimpanzees, and humans2015

    • Author(s)
      Sakai, T., Komaki, Y., Hata, J., Mikami, A., Matsui, M., Okahara, J., Okahara, N., Inoue, T., Sasaki, E., and Okano, H.
    • Organizer
      The 38nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2015-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト,チンパンジー,コモンマーモセットにおける脳梁発達の比較研究:ヒト特異的な脳構造の発達機構の解明に向けて2015

    • Author(s)
      酒井朋子, 三上章允, 小牧裕司, 畑純一, 畑純一, 松井三枝, 岡原純子, 岡原則夫, 井上貴司, 佐々木えりか, 濱田穣, 鈴木樹理, 宮部貴子, 松沢哲郎,岡野栄之
    • Organizer
      第31回日本霊長類学会大会
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2015-07-20
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒトとチンパンジーの脳発達:磁気共鳴画像法と超音波画像診断法を用いて2015

    • Author(s)
      酒井朋子
    • Organizer
      富山大学大学院医学薬学研究部(医学)心理学・認知神経科学セミナー
    • Place of Presentation
      富山大学(富山)
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Brain development in chimpanzees: a combined MRI and Ultrasound study2015

    • Author(s)
      Tomoko Sakai
    • Organizer
      Department of Radiology Seminar
    • Place of Presentation
      Johns Hopkins University School of Medicine(Baltimore)
    • Year and Date
      2015-02-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 霊長類の脳進化をたどる:磁気共鳴画像(MRI)法によるこれまでの歩みと今後の展望2015

    • Author(s)
      酒井朋子
    • Organizer
      第59回プリマーテス研究会
    • Place of Presentation
      公益財団法人日本モンキーセンター(愛知)
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
  • [Book] Mapping Evolution and Development of the Primate Brain by Neuroimaging Techniques2016

    • Author(s)
      Tomoko Sakai
    • Publisher
      Graduate School of Medicine and Pharmaceutical Science, University of Toyama
    • Related Report
      2016 Annual Research Report
  • [Book] Fetal Behavioral Development and Brain Growth in Chimpanzees Versus Humans: A View from Studies with 4D Ultrasonography2016

    • Author(s)
      Hideko Takeshita , Satoshi Hirata, Tomoko Sakai, Masako Myowa-Yamakoshi
    • Total Pages
      16
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Remarks] Department of Radiology, JHMI

    • URL

      http://www.hopkinsmedicine.org/radiology/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Center for Brain Imaging Science, JHMI

    • URL

      http://www.cis.jhu.edu/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Laboratory of Brain Anatomical MRI

    • URL

      http://lbam.med.jhmi.edu/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Laboratory of Brain Anatomical MRI

    • URL

      http://lbam.med.jhmi.edu

    • Related Report
      2015 Research-status Report
  • [Remarks] Susumu Mori

    • URL

      http://www.mri.kennedykrieger.org/susumumori.html

    • Related Report
      2015 Research-status Report
  • [Remarks] Kenichi Oishi

    • URL

      http://cmrm.med.jhmi.edu

    • Related Report
      2015 Research-status Report
  • [Remarks] 公益財団法人実験動物中央研究所

    • URL

      http://www.ciea.or.jp

    • Related Report
      2014 Research-status Report
  • [Remarks] 慶応義塾大学医学部生理学教室 岡野研 Weblog

    • URL

      http://www.okano-lab.com

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-01-27  

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