| Project/Area Number |
26870836
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic industrial materials
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Shiba Kota 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, ICYS研究員 (20638126)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ナノ粒子 / 機能性 / 単分散 / 無機有機ハイブリッド / マイクロリアクタ / 細胞毒性 |
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| Outline of Final Research Achievements |
To realize functional inorganic nanoparticles that are useful for cancer treatment, a novel synthetic approach was developed based on controlled sol-gel reaction using a microfluidic platform. Taking advantage of the present approach, various types of inorganic nanoparticles with different functionalities were obtained. Cell-particle interaction was investigated in detail with the fluorescent inorganic particles which were synthesized by the microfluidic approach. Consequently, a new concept, i.e. indirect and gradual molecular delivery, was proposed, demonstrating various merits over conventional drug delivery and/or bio-imaging techniques in terms of cytotoxicity, for example. The fluorescent inorganic particles also showed a characteristic luminescence property. Specifically, luminescence intensity varies reversely in air or in phosphate buffered saline depending on the amount of the fluorescent dye. These results provide a guideline on material design for various bio-applications.
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