| Project/Area Number |
26870846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
Neurochemistry/Neuropharmacology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Sato Ko 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90610395)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞内凝集 / 分子シャペロン / アルツハイマー病 / タンパク質品質管理 / 細胞内凝集体 |
|---|
| Outline of Final Research Achievements |
The aim of this study is to elucidate whether a molecular co-chaperone protein FK506 binding protein 5 (FKBP5) could be an ‘accelerator of intracellular aggregation’ in neurodegenerative diseases. In this study, I found that over expression of FKBP5 in Alzheimer’s disease model mouse show increase expression levels, highly phosphorylation and miss-localization of tau, a microtubule associated protein. On the other hand, I could not detect intracellular aggregation of tau. These results suggest that FKBP5 would not accelerate intracellular aggregation but modify Alzheimer’s disease pathology.
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