Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections
| Project/Area Number |
26870849
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
Parasitology (including sanitary zoology)
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| Research Institution | Gunma University (2015-2017)
The Institute of Physical and Chemical Research (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肥満細胞 / 感染免疫 / 寄生虫 / 腸管免疫 / IL-33 / ２型自然免疫リンパ球 / ILC2 / 寄生虫感染 / 消化管寄生蠕虫 / 自然リンパ球 / 寄生虫感染症 / M細胞 |
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| Outline of Final Research Achievements |
Mast cells are important for eradication of intestinal nematodes; however, their precise mechanisms of action have remained elusive. We found that Spi-B-deficient mice had increased numbers of mast cells and rapidly expelled the Heligmosomoides polygyrus (Hp). This was accompanied by induction of interleukin-13 (IL-13)-producing group 2 innate lymphoid cells (ILC2) and goblet cell hyperplasia. Immediately after Hp infection, mast cells were rapidly activated to produce IL-33 in response to ATP released from apoptotic intestinal epithelial cells. In vivo inhibition of the P2X7 ATP receptor rendered the Spi-B-deficient mice susceptible to Hp, concomitant with elimination of mast cell activation and IL-13-producing ILC2 induction. These results uncover a previously unknown role for mast cells in innate immunity in that activation of mast cells by ATP orchestrates the development of a protective type 2 immune response, in part by producing IL-33, which contributes to ILC2 activation.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis.2015
Author(s)
Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H, Horii T, Hisaeda H.
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Journal Title
Sci. Rep.
Volume: 5
Pages: 15699-15699
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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