Class switch of food-specific IgE, IgG4, IgA in infancy and prevention of food allergy
| Project/Area Number |
26870893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
Pediatrics
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| Research Institution | Hamamatsu University School of Medicine (2016-2017)
National Center for Child Health and Development (2014-2015) |
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Principal Investigator |
Natsume Osamu 浜松医科大学, 医学部, 助教 (20649115)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 食物アレルギー / 予防 / IgA / IgG4 / IgE / クラススイッチ / 耐性獲得 / 鶏卵アレルギー / 発症予防 / 早期摂取 / IgG1 / 卵アレルギー |
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| Outline of Final Research Achievements |
In order to develop a preventive method for the prevention of food allergy, we clarified that by eating eggs from a small amount from 6 months of age in infants with atopic dermatitis, the onset of egg allergy can be prevented compared with removal . As this mechanism, in addition to inhibiting IgE by eating, it was thought that blood IgG4 and IgA rise (immunoglobulin class switch occurs).
In milk allergy, it was suggested that ingestion of milk and milk protein continued from birth may reduce the incidence of cow's milk allergy. Even in this milk ingestion, IgG1, IgG4, and IgA are elevated like the egg, and I think that it is a similar mechanism.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2018
Author(s)
Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team.
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Journal Title
Lancet
Volume: 389
Pages: 276-276
Related Report
Peer Reviewed
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[Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2017
Author(s)
Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team..
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Journal Title
Lancet
Volume: 389
Issue: 10066
Pages: 276-286
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Continuous Cow’s Milk Protein Consumption from Birth and a Decrease in Milk Allergy: a Prospective Cohort Study Related to the PETIT Study2018
Author(s)
Osamu Natsume, Kiwako Yamamoto-Hanada, Shigenori Kabashima, Junko Nakazato, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Hiroshi Kido, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
Organizer
American Academy of allergy asthma and immunology annual meeting 2018
Related Report
Int'l Joint Research
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[Presentation] Early Introduction of Egg for Infants with Atopic Dermatitis to Prevent Egg Allergy2017
Author(s)
Osamu Natsume, Kiwako Yamamoto-Hanada, Shigenori Kabashima, Junko Nakazato, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Hiroshi Kido, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
Organizer
Korean Academy of asthma, allergy and clinical immunology Congress
Related Report
Int'l Joint Research
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[Presentation] arly introduction of egg for infants with atopic dermatitis to prevent egg allergy: A double-blind placebo-controlled randomized clinical trial2016
Author(s)
Osamu Natsume, Shigenori Kabashima, Junko Nakasato, Kiwako Yamamoto-Hanada, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Eisuke Inoue, Wakako Shinahara, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya
Organizer
2016 American Academy of Asthma, Allergy and Immunology Annual Meeting
Place of Presentation
ロサンゼルス
Year and Date
2016-03-05
Related Report
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