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Class switch of food-specific IgE, IgG4, IgA in infancy and prevention of food allergy

Research Project

Project/Area Number 26870893
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Pediatrics
Research InstitutionHamamatsu University School of Medicine (2016-2017)
National Center for Child Health and Development (2014-2015)

Principal Investigator

Natsume Osamu  浜松医科大学, 医学部, 助教 (20649115)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords食物アレルギー / 予防 / IgA / IgG4 / IgE / クラススイッチ / 耐性獲得 / 鶏卵アレルギー / 発症予防 / 早期摂取 / IgG1 / 卵アレルギー
Outline of Final Research Achievements

In order to develop a preventive method for the prevention of food allergy, we clarified that by eating eggs from a small amount from 6 months of age in infants with atopic dermatitis, the onset of egg allergy can be prevented compared with removal . As this mechanism, in addition to inhibiting IgE by eating, it was thought that blood IgG4 and IgA rise (immunoglobulin class switch occurs).
In milk allergy, it was suggested that ingestion of milk and milk protein continued from birth may reduce the incidence of cow's milk allergy. Even in this milk ingestion, IgG1, IgG4, and IgA are elevated like the egg, and I think that it is a similar mechanism.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Recent advancement to prevent the development of allergy and allergic diseases and therapeutic strategy in the perspective of barrier dysfunction2018

    • Author(s)
      Natsume Osamu、Ohya Yukihiro
    • Journal Title

      Allergology International

      Volume: 67 Issue: 1 Pages: 24-31

    • DOI

      10.1016/j.alit.2017.11.003

    • NAID

      130006322102

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2018

    • Author(s)
      Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team.
    • Journal Title

      Lancet

      Volume: 389 Pages: 276-276

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵の早期導入と卵アレルギー発症予防2018

    • Author(s)
      夏目統
    • Journal Title

      日本小児アレルギー学会誌

      Volume: 32 Pages: 27-27

    • NAID

      130006594416

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食物アレルギーの発症予防2018

    • Author(s)
      夏目統
    • Journal Title

      小児科臨床

      Volume: 1 Pages: 74-74

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2017

    • Author(s)
      Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team..
    • Journal Title

      Lancet

      Volume: 389 Issue: 10066 Pages: 276-286

    • DOI

      10.1016/s0140-6736(16)31418-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Continuous Cow’s Milk Protein Consumption from Birth and a Decrease in Milk Allergy: a Prospective Cohort Study Related to the PETIT Study2018

    • Author(s)
      Osamu Natsume, Kiwako Yamamoto-Hanada, Shigenori Kabashima, Junko Nakazato, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Hiroshi Kido, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
    • Organizer
      American Academy of allergy asthma and immunology annual meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early Introduction of Egg for Infants with Atopic Dermatitis to Prevent Egg Allergy2017

    • Author(s)
      Osamu Natsume, Kiwako Yamamoto-Hanada, Shigenori Kabashima, Junko Nakazato, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Hiroshi Kido, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
    • Organizer
      Korean Academy of asthma, allergy and clinical immunology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食物アレルギーへのEarly Intervention2017

    • Author(s)
      夏目統
    • Organizer
      第66回日本アレルギー学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 早期摂取による予防の試み2017

    • Author(s)
      夏目統
    • Organizer
      第34回日本小児難治喘息・アレルギー疾患学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 卵の早期導入と卵アレルギー発症予防2017

    • Author(s)
      夏目統
    • Organizer
      第54回日本小児アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 普通ミルクの摂取時期による牛乳アレルギーの発症予防効果2016

    • Author(s)
      夏目 統ら
    • Organizer
      日本小児アレルギー学会
    • Place of Presentation
      前橋
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] アトピー性皮膚炎乳児の鶏卵早期摂取による卵アレルギー発症予防についての無作為化二重盲検比較試験2016

    • Author(s)
      夏目 統ら
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] arly introduction of egg for infants with atopic dermatitis to prevent egg allergy: A double-blind placebo-controlled randomized clinical trial2016

    • Author(s)
      Osamu Natsume, Shigenori Kabashima, Junko Nakasato, Kiwako Yamamoto-Hanada, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Eisuke Inoue, Wakako Shinahara, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya
    • Organizer
      2016 American Academy of Asthma, Allergy and Immunology Annual Meeting
    • Place of Presentation
      ロサンゼルス
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 食物特異的IgGは食物アレルギーの診断に有用か2015

    • Author(s)
      夏目統,樺島重憲,山本貴和子,近藤麻伊,岸野愛,齋藤麻耶子,成田雅美,亀村典生,中里純子,元亜紀,橋本みゆき,小室久子,千葉剛史,稲垣真一郎,須田友子,二村昌樹,野村伊知郎,木戸博,大矢幸弘
    • Organizer
      第64回日本アレルギー学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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