Spectral imaging of blood flow in an artificial organ to promote it to an intelligent device
| Project/Area Number |
26870902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
SAKOTA DAISUKE 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 研究員 (40588670)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 血液 / 血栓 / ハイパースペクトラルイメージング / 人工心臓 / 体外補助循環 / 可視・近赤外分光 / 循環器デバイス / 近赤外分光 / 体外循環 |
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| Outline of Final Research Achievements |
Thrombus formation during mechanical circulatory support is one of the primary problem. We developed a hyperspectral imaging (HSI) method to visualize the thrombus growth process in a rotary blood pump. A hydrodynamically levitated centrifugal blood pump developed by our laboratory was used. The bottom surface of the pump was illuminated with white light pulsed at the same frequency as the pump rotation. Using stroboscopic HSI and an image construction algorithm, dynamic spectral imaging within the rotating pump was achieved. In vitro thrombogenic testing and animal experiment using swine of extracorporeal circulation was conducted to evaluate the developed imaging system. Both results showed successful imaging of the thrombogenic process in the pump. The non-invasive and real-time imaging technique of the thrombus formation would provide valuable information towards understanding the mechanism of thrombogenic process and optimal anticoagulation management.
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Report
(3 results)
Research Products
(24 results)
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[Presentation] Hyper-spectral imagingを用いたポンプ内血栓リアルタイムモニタリングシステムの大型動物実験における検証2015
Author(s)
藤原立樹, 迫田大輔, 大内克洋, 遠藤衆, 山野春樹, 田原禎生, 関晴永, 村重智崇, 小阪亮, 西田正浩, 丸山修, 荒井裕国
Organizer
定常流ポンプ研究会2015
Place of Presentation
東京ドームホテル, 東京
Year and Date
2015-11-19
Related Report
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[Presentation] The real-time optical monitoring of thrombus formaiton inside the blood pump during extracorporeal circulation using hyperspectral imaging in acute animal experiments2015
Author(s)
Tatsuki Fujiwara, Daisuke Sakota, Katsuhiro Ouchi, Tomotaka Murashige, Ryo Kosaka, Masahiro Nishida, Shu Endo, Eiki Nagaoka, Keiji Oi, Tomohiro Mizuno, Osamu Maruyama, Hirokuni Arai
Organizer
23rd Annual Congress of the International Society for Rotary Blood Pumps
Place of Presentation
Hotel Excelsior, Dubrovnik, Croatia
Year and Date
2015-09-27
Related Report
Int'l Joint Research
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[Presentation] Hyper-spectral imaging 法による血液ポンプ内血栓検出装置の大型動物実験における検証2015
Author(s)
藤原立樹, 迫田大輔, 大内克洋, 遠藤衆, 村重智崇, 田原禎生, 関晴永, 小阪亮, 丸山修, 荒井裕国
Organizer
第37回日本血栓止血学会学術集会
Place of Presentation
甲府市総合市民会館, 山梨
Year and Date
2015-05-21
Related Report
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