| Project/Area Number |
26870922
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
General surgery
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| Research Institution | Tottori University (2015-2016)
National Cardiovascular Center Research Institute (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 補助人工心臓 / 心拍変動解析 / 心不全 / 補助循環 / 心拍変動 / 大動物 / 心不全モデル |
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| Outline of Final Research Achievements |
Some patients who need to implant a left ventricular assist device (LVAD) due to severe heart failure may recover cardiac function and reach LVAD withdrawal. With LVAD, no indicator has been established to evaluate true heart function when stopping assistance. We focused on heart rate variability (HRV) analysis which estimating cardiac autonomic nervous function from electrocardiogram. In this study, a heart failure model was introduced for three goats and then LVAD was implanted, and the relationship between cardiac function and HRV was analyzed every week after operation. One goat was observed for 6 weeks after implanting LVAD. Recovery of cardiac function and an upward trend of HRV index were observed. It was suggested that hear rate variability may reflect cardiac function. In addition, we have prepared a system that can measure HRV even in clinical practice.
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