Kinetics of phenolic and methoxylated organohalogen compounds in lactation mouse and their infant-exposure assessment

• Project/Area Number: 26881008
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Daiichi University, College of Pharmaceutical Sciences
• Principal Investigator: Fujii Yukiko 第一薬科大学, 薬学部, 助教 (80733542)
• Co-Investigator(Renkei-kenkyūsha): HARAGUCHI Koichi 第一薬科大学, 薬学部, 教授 (00258500)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 母乳分泌 / 衛生学 / マウス / 体内動態 / 環境保健 / トキシコロジー

Outline of Final Research Achievements

Triclosan　(OH-TCS) is a phenolic organohalogen compound, which has been used for antibacterial agents. In this study, we administrated OH-TCS and methoxylated triclosan (M-TCS) to lactation mouse. After administration, 1) OH-TCS were metabolized to dihydroxide TCS (OH-OH-TCS). 2) M-TCS were metabolized to OH-TCS, OH-M-TCS, and OH-OH-TCS. OH-TCS were mainly distributed to blood and liver of the lactation mouse. On the other hands, M-TCS were mainly distributed to their adipose tissue and mammary gland. Administrated M-TCS were also detected in breast milk indicating the infant transfer via breast milk.

Research Products

• [Journal Article] Relationship between mercury, organochlorine compounds and stable isotope ratios of carbon and nitrogen in yellowfin tuna (Thunnus albacares) taken from different regions of the Pacific and Indian Oceans. (2016)
  • Author(s): Endo, T., Kimura, O., Fujii, Y., Haraguchi, K.
  • Journal Title: Ecological Indicators. Volume: 69 Pages: 340-347
  • DOI: 10.1016/j.ecolind.2016.04.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Metal Concentrations in the Liver and Stable Isotope Ratios of Carbon and Nitrogen in the Muscle of Silvertip Shark (Carcharhinus albimarginatus) Culled off Ishigaki Island, Japan (2016)
  • Author(s): Endo, T., Kimura, O., Ohta, C., Koga, N., Kato, Y., Fujii, Y., Haraguchi, K.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: 1-18
  • DOI: 10.1371/journal.pone.0147797
  • Peer Reviewed / Open Access
• [Journal Article] Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers (2016)
  • Author(s): Kimura, O., Fujii, Y., Haraguchi, K., Ohta, C., Koga, N., Kato, Y., Endo, T
  • Journal Title: Journal of Pharmacy and Pharmacology. Volume: - Issue: 7 Pages: 2042-7158
  • DOI: 10.1111/jphp.12557
  • Peer Reviewed / Open Access
• [Journal Article] Short-chain chlorinated paraffins in cooking oil and related products from China (2015)
  • Author(s): Cao, Y., Harada, K.H., Liu, W., Yan, J., Zhao, C., Niisoe, T., Adachi, A., Fujii, Y., Nouda, C., Takasuga, T., Koizumi, A.
  • Journal Title: Chemosphere Volume: 138 Pages: 104-111
  • DOI: 10.1016/j.chemosphere.2015.05.063
  • Peer Reviewed
• [Journal Article] Perfluorinated carboxylic acids discharged from the Yodo River Basin, Japan. (2015)
  • Author(s): Niisoe, T., Senevirathna, S.T., Harada, K.H., Fujii, Y., Hitomi, T., Kobayashi, H., Yan, J., Zhao, C., Oshima, M., Koizumi, A.
  • Journal Title: Chemosphere Volume: 138 Pages: 81-88
  • DOI: 10.1016/j.chemosphere.2015.05.060
  • Peer Reviewed
• [Journal Article] Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: a major source of human dietary exposure. (2015)
  • Author(s): Fujii Y, Sakurada T, Harada K, Koizumi A, Kimura O, Endo T, Haraguchi K.
  • Journal Title: Environ. Poll. Volume: 199 Pages: 35-41
  • DOI: 10.1016/j.envpol.2015.01.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans (2015)
  • Author(s): Fujii Y, Niisoe T, Harada K, Uemoto S, Ogura Y, Takenaka K, Koizumi A.
  • Journal Title: Journal of Occupational Health Volume: 57 Issue: 1 Pages: 1-12
  • DOI: 10.1539/joh.14-0136-OA
  • NAID: 130004713080
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed
• [Journal Article] Pentafluorobenzyl esterification of haloacetic acids in tap water for simple and sensitive analysis by gas chromatography/mass spectrometry with negative chemical ionization. (2015)
  • Author(s): Zhao C, Fujii Y, Yan J, Harada K, Koizumi A.
  • Journal Title: Chemosphere Volume: 119 Pages: 711-718
  • DOI: 10.1016/j.chemosphere.2014.07.048
  • Peer Reviewed
• [Presentation] Gossypetin hexamethyletherの動物肝ミクロゾームによる代謝 (2016)
  • Author(s): 太田千穂、山本健太、藤井由希子、原口浩一、木村 治、遠藤哲也、加藤善久、古賀信幸
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-13
• [Presentation] ツマジロザメの成長に伴う肝臓中有害金属濃度と必須金属濃度の変化 (2016)
  • Author(s): 遠藤哲也、木村 治、太田千穂、古賀信幸、加藤善久、藤井由希子、原口浩一
  • Organizer: 平成28年度 日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2016-03-26
• [Presentation] Caco-2 細胞におけるアリストロキア酸 I の膜透過に及ぼすケルセチンの影響 (2016)
  • Author(s): 木村治、 藤井 由希子、原口浩一 、太田千穂、古賀信幸、加藤善久、遠藤哲也
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-26
• [Presentation] 海藻食品に由来するヒト血液および尿中6-OH-BDE47の抱合体 (2016)
  • Author(s): 高木雅恵、森山綾香、藤井由希子、原口浩一、太田千穂、古賀信幸、加藤善久、木村 治、遠藤哲也
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-26
• [Presentation] 大型海洋ほ乳類を用いた有機フッ素化合物の肝臓蓄積実態の解明 (2016)
  • Author(s): 木下真璃伽、久我歩佳、藤井由希子、加藤善久、木村 治、遠藤哲也、太田千穂、古賀信幸、原口浩一
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-26
• [Presentation] 北海道沿岸に漂着したクジラ・イルカの残留性フッ素化合物の分析 (2015)
  • Author(s): 森 稜太、深水 彰徳 、藤井 由希子、加藤 善久、木村 治、遠藤 哲也、原口 浩一
  • Organizer: 日本分析化学会第64年会
  • Place of Presentation: 九州大学
  • Year and Date: 2015-09-09
• [Presentation] イタチザメの成長に伴う水銀分布と炭素および窒素安定同位体比の変化 (2015)
  • Author(s): 遠藤哲也、木村治、小笠原英樹、太田千穂、古賀信幸、加藤善久、藤井由希子、原口浩一
  • Organizer: 平成27年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-27 – 2015-03-31
• [Presentation] メチルトリクロサンのマウス代謝活性化と乳汁分泌 (2015)
  • Author(s): 久我歩佳、木下真璃伽、藤井由希子、櫻田司、原口浩一、太田千穂、古賀信幸、遠藤哲也
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 海藻で生産される臭素化ビフェノール類の機能性評価 (2015)
  • Author(s): 小栁侑平、河野龍海、高木雅恵、森山綾香、藤井由希子、松原 大、原口浩一、太田千穂,古賀信幸
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] A MAJOR SOURCE OF DIETARY EXPOSURE TO LONG-CHAIN PERFLUORINATED CARBOXYLIC ACIDS (2015)
  • Author(s): Fujii, Yukiko; Sakurada, Tsukasa; Kuga, Ayuka; Kinoshita, Marika; Harada, Kouji; Koizumi, Akio; Kimura, Osamu; Endo, Tetsuya; Haraguchi, Koichi.
  • Organizer: Society of Toxicology 54th Annual Meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2015-03-22 – 2015-03-26
• [Presentation] HUMAN EXPOSURE TO HYDROXYLATED PBDE: SEAWEEDS AS DIETARY SOURCE (2015)
  • Author(s): Takagi, Masae; Koyanagi, Yuhei; Moriyama, Ayaka; Kawano, Tatsumi; Fujii, Yukiko; Endo, Tetsuya; Haraguchi, Koichi,
  • Organizer: Society of Toxicology 54th Annual Meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2015-03-22 – 2015-03-26
• [Presentation] CONTAMINATION TRENDS OF HEXABROMOCYCLODODECANES,TRIBROMOPHENOL AND TETRABROMOBISPHENOL A IN JAPANESE (2015)
  • Author(s): Haraguchi, Koichi; Fujii, Yukiko; Kato, Yoshihisa.
  • Organizer: Society of Toxicology 54th Annual Meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2015-03-22 – 2015-03-26