| Project/Area Number |
26881008
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
|---|
Principal Investigator |
Fujii Yukiko 第一薬科大学, 薬学部, 助教 (80733542)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HARAGUCHI Koichi 第一薬科大学, 薬学部, 教授 (00258500)
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 母乳分泌 / 衛生学 / マウス / 体内動態 / 環境保健 / トキシコロジー |
|---|
| Outline of Final Research Achievements |
Triclosan (OH-TCS) is a phenolic organohalogen compound, which has been used for antibacterial agents. In this study, we administrated OH-TCS and methoxylated triclosan (M-TCS) to lactation mouse. After administration, 1) OH-TCS were metabolized to dihydroxide TCS (OH-OH-TCS). 2) M-TCS were metabolized to OH-TCS, OH-M-TCS, and OH-OH-TCS. OH-TCS were mainly distributed to blood and liver of the lactation mouse. On the other hands, M-TCS were mainly distributed to their adipose tissue and mammary gland. Administrated M-TCS were also detected in breast milk indicating the infant transfer via breast milk.
|
