Searching for a valid hemodynamic parameters for thrombus formation around intracranial stent

• Project/Area Number: 26882002
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Anzai Hitomi 東北大学, 学際科学フロンティア研究所, 助教 (50736981)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳動脈瘤 / ステント / in vitro実験 / 内皮細胞 / 医療デバイス / 血栓 / in vitro試験 / 血流

Outline of Final Research Achievements

The aim of this study is to clarify the relationship between hemodynamic parameters and thrombus formation around medical implants. We developed in vitro system with cavity flow chamber for goat blood. This system can develop the flow environment under low Reynolds number <100 observed in human brain aneurysm. We also performed cell experiment with NiTi metallic wire. The results show inhomogeneous cell distribution depending on surface treatment of wire and wire structure.

Research Products

• [Journal Article] Porosity Dependency of an Optimized Stent Design for Intracranial Aneurysm (2015)
  • Author(s): H. Anzai, Y. Yoshida, S. Sugiyama, H. Endo, Y. Matsumoto, M. Ohta
  • Journal Title: Technology and Health Care Volume: 23 Pages: 547-556
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Parametric study of porous media as substitutes for flow-diverter stent (2015)
  • Author(s): Makoto Ohta, Hitomi Anzai, Yukihisa Miura and Toshio Nakayama
  • Journal Title: [Biomaterials and Biomedical Engineering Volume: 2 Issue: 2 Pages: 111-125
  • DOI: 10.12989/bme.2015.2.2.111
  • Peer Reviewed
• [Presentation] Flow Simulations to Establish the Relationship between the Inflow Zone in the Neck of a Cerebral Aneurysm and the Positions of Struts (2016)
  • Author(s): K. Watanabe, H. Anzai, M. Ohta
  • Organizer: International Mechanical Engineering Congress & Exposition (IMECE2016)
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] Computational fluid dynamics analysis of the bone marrow in cancellous bone as a non-Newtonian fluid (2016)
  • Author(s): M. Ohta, W. Sakuma, T. Nakayama, H. Anzai, M. Ito, K. Sado, S. Nakamura
  • Organizer: International Mechanical Engineering Congress & Exposition (IMECE2016)
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] 低レイノルズ数領域における 血液環流フローチャンバーシステムの開発 (2016)
  • Author(s): 安西眸，白石泰之，山家智之，太田信
  • Organizer: 第39回日本バイオレオロジー学会年会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
• [Presentation] AVEC CFD 2016 (2016)
  • Author(s): 安西眸，Simon Tupin，渡邉 和浩，Sherif Rashad，太田信
  • Organizer: 第39回日本バイオレオロジー学会年会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18
• [Presentation] Optimal interval of two strut wires relative to aneurysm inflow (2016)
  • Author(s): H. Anzai, K. Watanabe, M. Ohta
  • Organizer: European Congress on Computational Methods in Applied Sciences and Engineering (eccomas 2016)
  • Place of Presentation: Crete Island, Greece
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Presentation] Development of in-vitro and in-silico model for evaluating medical devices (2015)
  • Author(s): Makoto Ohta, Kaihong Yu, Ren Takahashi, Yuta Muramoto, Wataru Sakuma, Taihei Onishi, Hitomi Anzai
  • Organizer: Beijing-Tohoku Biomechanics Symposium
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-11-25
  • Int'l Joint Research
• [Presentation] Optimization of Flow Diverter design (2015)
  • Author(s): Makoto Ito, Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: Beijing-Tohoku Biomechanics Symposium
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-11-25
  • Int'l Joint Research
• [Presentation] Co-relationship between Hemodynamics and Optimal Stent Structure (2015)
  • Author(s): Hitomi Anzai, Kazuhiro Watanabe, Yuuki Yoshida, Koji Shimoyama, Shigeru Obayashi, Makoto Ohta
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Towards the Patient-specific Design of Intracranial Stents for Advanced Flow Diversion Efficacy (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] In-Vitro Model and Cell Behaviors (2015)
  • Author(s): Makoto Ohta, Tomohito Watanabe, Xiaobo Han, Kaihong Yu, Taihei Onishi, Hitomi Anzai
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Visualization of Flow Patterns through the Aneurysmal Orifice after Flow Diverter Optimizations with Different Objective Functions (2015)
  • Author(s): Zhang M, Anzai H, Ohta M
  • Organizer: [Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Analysis of Relationship Between Stent Structure and Flow Stagnation Using Self-Organizing Maps for Realistic Aneurysm (2015)
  • Author(s): Anzai H, Yoshida Y, Shimoyama K, Obayashi S, Ohta M
  • Organizer: Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 2015-11-13
  • Int'l Joint Research / Invited
• [Presentation] Cell density distribution around the wire with flow condition (2015)
  • Author(s): Tomohito Watanabe, Han Xiaobo, Makoto Ohta,Hitomi Anzai, Hisatoshi Kobayashi
  • Organizer: [The Fifteenth International Symposium on Advanced Fluid Information
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (third report) (2015)
  • Author(s): Makoto Ohta, Mingzi, Zhang, Bastien Chopard, Xiaobo Han, Yujie Li, Hitomi Anzai
  • Organizer: AFI-TFI
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] CFD Alanyses for the flow in Cancellous Bone with LBM (2015)
  • Author(s): Wataru Sakuma, Toshio Nakayama, Hitomi Anzai, Shuji Nakamura, Katsuyuki Sado, Konstantin Kutscher, Martin Geier, Manfred Krafczyk, Makoto Ohta
  • Organizer: The 8th Asian-Pacific Conference on Biomechanics
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] Searching for valuable hemodynamic parameters for applying to optimization study (2015)
  • Author(s): Hitomi Anzai
  • Organizer: The 9th European Solid Mechanics Conference
  • Place of Presentation: マドリード
  • Year and Date: 2015-07-06 – 2015-07-10
• [Presentation] Searching for valuable hemodynamic parameters for applying to optimization study (2015)
  • Author(s): Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta
  • Organizer: 9th European Solid Mechanics Conference,
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-07-06
  • Int'l Joint Research / Invited
• [Presentation] Introduction of Optimization of Design using Combination of Lattice Boltzmann Method as CFD and Simulated Annealing for Reduction of Flow Speed (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: 1st NUAA-Tohoku University Joint Symposium on Fluid Science
  • Place of Presentation: Nanjing, China
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: 11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11)
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-06-07
  • Int'l Joint Research
• [Presentation] Optimization of endovascular prosthesis for the treatment ofcerebral aneurysms (2015)
  • Author(s): Hitomi Anzai
  • Organizer: 2015 ELyT lab Workshop
  • Place of Presentation: 松島
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] Production and characterization of composite materials for bones-biomodeling (2015)
  • Author(s): Wataru Sakuma
  • Organizer: 2015 ELyT lab Workshop
  • Place of Presentation: 松島
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] 脳動脈瘤内の血液凝固促進を目指したステントデザインの最適化 (2014)
  • Author(s): 吉田裕貴
  • Organizer: 日本機械学会第11回最適化シンポジウム2014
  • Place of Presentation: 金沢
  • Year and Date: 2014-12-12 – 2014-12-13
• [Presentation] 実形状海綿骨内の数値流体力学解析 (2014)
  • Author(s): 佐久間航
  • Organizer: 日本機械学会第27回計算力学講演会
  • Place of Presentation: 岩手
  • Year and Date: 2014-11-22 – 2014-11-24
• [Presentation] A Comparison of Experimental and CFD Analyses for Permeability of Cancellous Bone (2014)
  • Author(s): Wataru Sakuma
  • Organizer: 1st International symposium for collaborative research between Tohoku University and Technische Universit&#228;t Braunschweig
  • Place of Presentation: ブラウンシュバイク
  • Year and Date: 2014-11-11
• [Presentation] Automation of design optimization for intracranial stent (2014)
  • Author(s): Hitomi Anzai
  • Organizer: 1st International symposium for collaborative research between Tohoku University and Technische Universit&#228;t Braunschweig
  • Place of Presentation: ブラウンシュバイク
  • Year and Date: 2014-11-11
• [Presentation] A Development of Manufactureoriented Optimization Strategy for Flow Diverter Stent based on Cylindrical Spirals (2014)
  • Author(s): Mingzi Zhang
  • Organizer: 11th International Conference on Flow Dynamics (ICFD2014)
  • Place of Presentation: 仙台
  • Year and Date: 2014-10-08 – 2014-10-10
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (Second report) (2014)
  • Author(s): Makoto Ohta
  • Organizer: The Fourteenth International Symposium on. Advanced Fluid Information
  • Place of Presentation: 仙台
  • Year and Date: 2014-10-08
• [Presentation] Modeling of Cortical Bone and Bone Marrow (2014)
  • Author(s): Makoto Ohta
  • Organizer: The Fourteenth International Symposium on. Advanced Fluid Information
  • Place of Presentation: 仙台
  • Year and Date: 2014-10-08
• [Presentation] 数値流体力学に基づくステントストラット配置最適化 (2014)
  • Author(s): 安西眸
  • Organizer: 日本流体力学会年会2014
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-15 – 2014-09-17
• [Presentation] Optimization of stent design for intracranial aneurysm (2014)
  • Author(s): Hitomi Anzai
  • Organizer: The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重
  • Year and Date: 2014-09-01 – 2014-09-04
• [Presentation] An Optimization Method of FD Stent for Cerebral Aneurysm facing tne Stent Design and Manufacturing Needs (2014)
  • Author(s): Mingzi Zhang
  • Organizer: Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重
  • Year and Date: 2014-09-01 – 2014-09-04
• [Presentation] Development of Image Guided Minimal Invasive Treatments (2014)
  • Author(s): Makoto Ohta
  • Organizer: Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重
  • Year and Date: 2014-09-01
• [Remarks] 東北大学流体科学研究所 太田研究室 ホームページ
  • URL: http://www.ifs.tohoku.ac.jp/bfc/