Transcription factor complex formation and gene expression control in energy metabolism

Research Project

Project/Area Number	26882008
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Applied health science
Research Institution	University of Tsukuba
Principal Investigator	HAN SONGIEE 筑波大学, 医学医療系, 研究員 (80729541)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	CREBH / 転写因子複合体 / エネルギー代謝
Outline of Final Research Achievements	CREBH is a transcription factor, which is expressed in liver and intestine. CREBH regulates whole-body lipid metabolism. CREBH can bind to PPARα and its co-activator PGC-1α, leading to activation of FGF21 expression. CREBH also binds to SREBP, a master regulator for fatty acid and cholesterol synthesis. This association suppressed the transcriptional activity of SREBP. We identify that the cross-talk among CREB3L3 and transcription factors maintains energy homeostasis and improves metabolic syndrome. We developed liver-specific CREBH KO mice using one-step CRISSPR/Cas9 system. We find the deficiency of CREBH in liver leads to non-alcoholic fatty liver disease.

Report

(3 results)