An implantable neural bidirectional device for behavior experiments of small animals

• Project/Area Number: 26882027
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Brain biometrics
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Haruta Makito 奈良先端科学技術大学院大学, 物質創成科学研究科, 博士研究員 (40733663)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: CMOSイメージセンサ / 脳機能イメージング / 脳血流計測 / オプトジェネティクス / 生体埋植デバイス / 多点光刺激

Outline of Final Research Achievements

We have developed an implantable neural bidirectional device for understanding brain functions in behavior experiments of small animals. This device has two functions which are optically detecting and controlling brain activities. In this study, we achieved the following results; (1) The device weights about 0.2 g which is much lighter than the weight of an adult mouse. (2) The device detected brain activities in the smart somatosensory cortex when the frontal limb was stimulated. (3) The device controlled brain activities using multi optical stimulations in a brain of channelrhodopsin2-NestinCre transgenic mice.

Research Products

• [Journal Article] Intrinsic signal imaging of brain function using a small implantable CMOS imaging device (2014)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Journal Title: Japanese Journal of Applied Physics Volume: 54 Issue: 4S Pages: 04DL10-04DL10
  • DOI: 10.7567/jjap.54.04dl10
  • NAID: 210000145072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] An implantable hemodynamic imaging device for revealing relation between a blood flow and brain activity in animal behavior (2015)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara.Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: Neuroscience2015 SfN 45th annual meeting
  • Place of Presentation: Chicago(USA)
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] An Implantable Hemodynamic Imaging Device for Observing the Process of Recovery from Cerebrovascular Disease (2015)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano(Italy)
  • Year and Date: 2015-08-28
  • Int'l Joint Research
• [Presentation] An implantable hemodynamic imaging device with a two-color light source for observing two brain phenomena (2015)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 2015 INTERNATIONAL SYMPOSIUM FOR ADVANCED MATERIALS RESEARCH
  • Place of Presentation: 南投県魚池郷(台湾)
  • Year and Date: 2015-08-19
  • Int'l Joint Research / Invited
• [Presentation] 動物の脳機能制御を可能にする無線多点光刺激デバイス (2015)
  • Author(s): Makito Haruta, , Naoya Kamiyama, Takahiro Yamaguchi, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] 埋め込み可能な小型脳血流イメージングデバイスの開発 (2015)
  • Author(s): 春田 牧人, 須永 圭紀, 山口 貴大, 竹原 浩成 太田 安美, 元山 真由美, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇 , 太田 淳
  • Organizer: E部門総合研究会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県福岡市）
  • Year and Date: 2015-07-03
• [Presentation] An implantable optogenetics device based on CMOS integrated circuit technology for a freely moving animal (2014)
  • Author(s): Makito Haruta, Naoya Kamiyama, Shun Nakajima, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: Neuroscience2014
  • Place of Presentation: Washington(USA)
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 行動実験を目的とした埋植用CMOSイメージングデバイスによる脳機能イメージング (2014)
  • Author(s): 春田 牧人, 須永 圭紀, 山口 貴大, 竹原 浩成, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 日本神経科学大会(Neuroscience2014)
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] A multi-modal implantable CMOS imaging device with two-color light source for intrinsic signal detection in a brain (2014)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: International Conference on Solid State Devices and Materials (SSDM)
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2014-09-08 – 2014-09-11