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An implantable neural bidirectional device for behavior experiments of small animals

Research Project

Project/Area Number 26882027
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Brain biometrics
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Haruta Makito  奈良先端科学技術大学院大学, 物質創成科学研究科, 博士研究員 (40733663)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsCMOSイメージセンサ / 脳機能イメージング / 脳血流計測 / オプトジェネティクス / 生体埋植デバイス / 多点光刺激
Outline of Final Research Achievements

We have developed an implantable neural bidirectional device for understanding brain functions in behavior experiments of small animals. This device has two functions which are optically detecting and controlling brain activities. In this study, we achieved the following results; (1) The device weights about 0.2 g which is much lighter than the weight of an adult mouse. (2) The device detected brain activities in the smart somatosensory cortex when the frontal limb was stimulated. (3) The device controlled brain activities using multi optical stimulations in a brain of channelrhodopsin2-NestinCre transgenic mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (9 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Intrinsic signal imaging of brain function using a small implantable CMOS imaging device2014

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 54 Issue: 4S Pages: 04DL10-04DL10

    • DOI

      10.7567/jjap.54.04dl10

    • NAID

      210000145072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] An implantable hemodynamic imaging device for revealing relation between a blood flow and brain activity in animal behavior2015

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara.Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      Neuroscience2015 SfN 45th annual meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Implantable Hemodynamic Imaging Device for Observing the Process of Recovery from Cerebrovascular Disease2015

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano(Italy)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An implantable hemodynamic imaging device with a two-color light source for observing two brain phenomena2015

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      2015 INTERNATIONAL SYMPOSIUM FOR ADVANCED MATERIALS RESEARCH
    • Place of Presentation
      南投県魚池郷(台湾)
    • Year and Date
      2015-08-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 動物の脳機能制御を可能にする無線多点光刺激デバイス2015

    • Author(s)
      Makito Haruta, , Naoya Kamiyama, Takahiro Yamaguchi, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 埋め込み可能な小型脳血流イメージングデバイスの開発2015

    • Author(s)
      春田 牧人, 須永 圭紀, 山口 貴大, 竹原 浩成 太田 安美, 元山 真由美, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇 , 太田 淳
    • Organizer
      E部門総合研究会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] An implantable optogenetics device based on CMOS integrated circuit technology for a freely moving animal2014

    • Author(s)
      Makito Haruta, Naoya Kamiyama, Shun Nakajima, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      Neuroscience2014
    • Place of Presentation
      Washington(USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 行動実験を目的とした埋植用CMOSイメージングデバイスによる脳機能イメージング2014

    • Author(s)
      春田 牧人, 須永 圭紀, 山口 貴大, 竹原 浩成, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      日本神経科学大会(Neuroscience2014)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] A multi-modal implantable CMOS imaging device with two-color light source for intrinsic signal detection in a brain2014

    • Author(s)
      Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      International Conference on Solid State Devices and Materials (SSDM)
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-09-08 – 2014-09-11
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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