| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, design and synthesis of dynamic planar-chiral cyclic amines were carried out. The stereochemical analysis of newly obtained planar-chiral cyclic amines revealed that they can be racemized rapidly at room temperature. Control of their dynamic stereochemical behavior by using intramolecular hydrogen bond or coordination of metal complexes were also examined. In addition, stereospecific transformation methods of optically active planar-chiral cyclic amines to central chiral molecules were developed. For example, transannular reaction with strong base and epoxidation proceeded stereospecifically. Furthermore, enantioselective synthesis of planar chiral cyclic amines was accomplished based on the Pd-catalytzed asymmetric cyclization reaction.
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