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Development of surface plasmon-enhanced fluorescence biosensor for early detection of biomarkers

Research Project

Project/Area Number 26889025
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Toma Koji  東京医科歯科大学, 生体材料工学研究所, 助教 (40732269)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords表面プラズモン / バイオセンサ / 蛍光
Outline of Final Research Achievements

The purpose of this research was to develop an optical biosensor that enables sensitive measurement of marker biomolecules which are used to estimate a potential risk of diseases. In fiscal year 2014, a proper structure or material of a sensor chip were investigated by simulation, and an experimental setup and its controlling system were developed. In fiscal year 2015 year, along with optimizing and tuning the development of the setup and the system, a model sample of microparticles which correlate to inflammatory diseases, autoimmune disorder, and malignancies was measured. It was observed that the sensor output increased with increased concentration of the sample.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2015 2014

All Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Label-free high resolution surface plasmon microscopy for quantitative cell-gold interface investigation2015

    • Author(s)
      Koji Toma
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repetitive immunosensing with a highly stable protein monolayer and surface acoustic wave device for allergen monitoring2015

    • Author(s)
      Koji Toma
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repetitive immunoassay with a regeneration resistant protein and surface acoustic wave device for allergen monitoring2015

    • Author(s)
      Koji Toma
    • Organizer
      EuroAnalysis 2015
    • Place of Presentation
      Bordeaux, France
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Label-free measurement of cell-gold cleft gap distance using surface plasmon microscopy2015

    • Author(s)
      Koji Toma
    • Organizer
      Pittcon 2015
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Label-free investigation of cell-electrode interface with surface plasmon microscopy2014

    • Author(s)
      Koji Toma
    • Organizer
      International Conference on BioSensors,BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2014
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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