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Molecular and neurophysiological basis of the functional regulation of nociceptive sensory neurons by the BMP signaling pathway

Research Project

Project/Area Number 26890025
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Tsukuba (2015)
National Institute of Genetics (2014)

Principal Investigator

HONJO Ken  筑波大学, 生命環境系, 特任助教 (50731866)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsショウジョウバエ / 侵害受容 / 痛覚 / BMP
Outline of Final Research Achievements

In my previous study, it has been suggested that the activation of BMP signaling pathway in nociceptive sensory neurons leads to a sensitized nociception. In this study, I established a new imaging method to observe responses of nociceptive sensory neurons in vivo. Using the imaging technique, I found that the neuronal responses to noxious heat was abnormally exaggerated in nociceptive sensory neurons with hyperactive BMP signaling. This result raises the possibility that BMP signaling can be a regulator of nociception which controls it through regulating neurophysiological functions of nociceptive sensory neurons.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] ショウジョウバエにおいてユビキチン-プロテアソーム系はBMPシグナル経路の抑制調節を通じ侵害受容ニューロン機能を調節する2014

    • Author(s)
      本庄 賢、鈴木 えみ子、Dan Tracey
    • Organizer
      第37回日本神経科学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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