| Project/Area Number |
26890025
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Tsukuba (2015)
National Institute of Genetics (2014) |
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Principal Investigator |
HONJO Ken 筑波大学, 生命環境系, 特任助教 (50731866)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ショウジョウバエ / 侵害受容 / 痛覚 / BMP |
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| Outline of Final Research Achievements |
In my previous study, it has been suggested that the activation of BMP signaling pathway in nociceptive sensory neurons leads to a sensitized nociception. In this study, I established a new imaging method to observe responses of nociceptive sensory neurons in vivo. Using the imaging technique, I found that the neuronal responses to noxious heat was abnormally exaggerated in nociceptive sensory neurons with hyperactive BMP signaling. This result raises the possibility that BMP signaling can be a regulator of nociception which controls it through regulating neurophysiological functions of nociceptive sensory neurons.
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