Analysis of 3'-end formation mechanism of piRNAs involved in the silencing of transposons
| Project/Area Number |
26891004
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Izumi Natsuko 東京大学, 分子細胞生物学研究所, 助教 (50579274)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | RNAサイレンシング / 発現制御 / ゲノム / 核酸 |
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| Outline of Final Research Achievements |
A class of small RNAs called PIWI-interacting RNAs (piRNAs) plays an important role in protecting the germline genome from the threat of transposons. This study identified “Trimmer” the enzyme that trims the 3’ end of precursor piRNAs to generate mature piRNAs, and demonstrated the mechanism and significance of piRNA maturation.
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Report
(3 results)
Research Products
(7 results)
