| Project/Area Number |
26891012
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
SHINDO Asako 名古屋大学, 理学(系)研究科(研究院), 助教 (60512118)
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| Project Period (FY) |
2014-08-29 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 創傷治癒 / 細胞集団 / 細胞骨格 / 細胞生物学 / アフリカツメガエル |
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| Outline of Final Research Achievements |
Collective cell movement is a fundamental cellular event for tissue morphogenesis and repair. The molecular mechanisms of the coordinated cell behaviors are largely unknown. In this research, we have focus on embryonic epithelial wound healing as a model, and analyzed the process of cell shape change and cell movement. It has been known that the driving force for cell movement during embryonic wound closure is contractile force generated by actomyosin at the wound edge. We have found that the actomyosin requires septins, a cytoskeletal element, to close the wound. We concluded that septins controls cell shape and movement to coordinate the collective cell movement in the tissue via actomyosin.
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