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Spatial and temporal regulation of membrane dynamics during cytokinesis

Research Project

Project/Area Number 26891017
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionOkayama University

Principal Investigator

Takeda Tetsuya  岡山大学, 医歯(薬)学総合研究科, 助教 (30302368)

Research Collaborator TAKEI Kohji  岡山大学, 大学院医歯薬学総合研究科, 教授 (40322226)
Uchihashi Takayuki  金沢大学, 数物科学系, 教授 (30326300)
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords細胞質分裂 / F-BAR
Outline of Final Research Achievements

F-BAR domain protein Syndapin is essential for membrane dynamics during cytokinesis. Syndapin is phosphoregulated in cytokinesis but responsible kinases and phosphatases remained unclear. In this study, we identified PP1 phosphatases are required for Syndapin localisation to the cleavage furrow during cytokinesis. Furthermore, one of the essential mitotic kinases Plk1 directly phosphorylated Syndapin in vitro. These results suggested that Syndapin function during cytokinesis is spatially and temporally phosphoregulated by counter action of PP1 phosphatases and Polo-like kinase.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Membrane Dynamics during Cytokinesis2016

    • Author(s)
      竹田哲也
    • Journal Title

      Seibutsu Butsuri

      Volume: 56 Issue: 1 Pages: 013-017

    • DOI

      10.2142/biophys.56.013

    • NAID

      130005121650

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone.2015

    • Author(s)
      Yamada H, Kikuchi T, Masumoto T, Wei FY, Abe T, Takeda T, Nishiki T, Tomizawa K, Watanabe M, Matsui H, Takei K.
    • Journal Title

      Biology of the Cell

      Volume: 107 Issue: 9 Pages: 319-330

    • DOI

      10.1111/boc.201500032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] ダイナミン複合体による膜リモデリングの高速原子間力顕微鏡解析2016

    • Author(s)
      竹田 哲也、熊谷 祐介、背山 佳穂、楊 恵然、山田 浩司、田岡 東、内橋 貴之、竹居 孝二、安藤 敏夫
    • Organizer
      2016年生体運動合同班会議
    • Place of Presentation
      キャンパスプラザ京都
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎糸球体ポドサイト分化におけるダイナミンGTPアーゼの役割2015

    • Author(s)
      橘 洋美、竹田 哲也、山田 浩司、小川 大輔、竹居 孝二
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 成長円錐におけるPKCαのコルタクチンリン酸化によるアクチン制御の可能性2015

    • Author(s)
      山田 浩司、菊池 達也、増本 年男、魏 范研、阿部 匡史、竹田 哲也、西木 禎一、富澤 一仁、渡部 昌実、松井 秀樹、竹居 孝二
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダイナミンによる膜切断メカニズムの高速AFMイメージング解析2015

    • Author(s)
      竹田 哲也、熊谷 祐介、背山 佳穂、楊 恵然、山田 浩司、田岡 東、内橋 貴之、竹居 孝二、安藤 敏夫
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞質分裂における膜リモデリング機構の解析2015

    • Author(s)
      竹田哲也
    • Organizer
      2015年生体運動合同班会議
    • Place of Presentation
      学習院大学
    • Year and Date
      2015-01-07 – 2015-01-09
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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