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Molecular mechanism of melanopsin to induce non-image forming responses

Research Project

Project/Area Number 26891022
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionKeio University

Principal Investigator

Hatori Megumi  慶應義塾大学, 医学部, 准教授 (90590472)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsメラノプシン / 概日リズム / 網膜 / 光受容
Outline of Final Research Achievements

Melanopsin photopigment expressed in intrinsically photosensitive retinal ganglion cells plays a crucial role in the adaptation of mammals to ambient light environment through both image-forming and non-image-forming visual responses. The melanopsin-expressing retinal ganglion cells are structurally and functionally distinct from classical rod/cone photoreceptors and have unique properties, including single-photon response, long response latency, photon integration over time, and slow deactivation. To understand the molecular property of melanospin, I generated various mutant versions of melanopsin, and these proteins were expressed in mammalian cells. Blue light-dependent increases in cytosolic calcium were monitored. By using this assay system, several of mutant melanopsin were obtained to show in vitro response difference compared to wild type melanopsin, and the effect of these mutant melanopsin on non-image forming responses will be evaluated in vivo in mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (6 results) (of which Invited: 4 results)

  • [Journal Article] 時計システムと老化2016

    • Author(s)
      津山 淳、羽鳥 恵
    • Journal Title

      日本臨床

      Volume: -

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ブルーライト研究の歴史と概日時計との関わり2016

    • Author(s)
      羽鳥 恵
    • Journal Title

      ブルーライトテキストブック

      Volume: -

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 網膜 - 視床下部の光応答2016

    • Author(s)
      羽鳥 恵
    • Journal Title

      光と生命の事典

      Volume: - Pages: 214-215

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Response of peripheral rhythms to the timing of food intake.2015

    • Author(s)
      Hatori M and Panda S
    • Journal Title

      Methods in Enzymology

      Volume: 552 Pages: 145-161

    • DOI

      10.1016/bs.mie.2014.10.027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 体内時計への入力2015

    • Author(s)
      羽鳥 恵
    • Journal Title

      Medical Science Digest

      Volume: 41 Pages: 382-385

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 体内時計と眼2015

    • Author(s)
      羽鳥 恵、坪田 一男
    • Journal Title

      アンチ・エイジング医学

      Volume: 11 Pages: 385-392

    • NAID

      40020527265

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 概日リズムと老化2015

    • Author(s)
      羽鳥 恵
    • Journal Title

      第三版アンチエイジング医学の基礎と臨床

      Volume: - Pages: 65-66

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 眼と時間生物学2015

    • Author(s)
      羽鳥 恵
    • Journal Title

      眼科研修ノート 改訂第2版

      Volume: - Pages: 445-447

    • Related Report
      2015 Annual Research Report
  • [Presentation] 概日リズムと老化2016

    • Author(s)
      羽鳥 恵
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      大手町サンケイプラザ(東京都千代田区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 概日時計と外界環境との調和機構2015

    • Author(s)
      羽鳥 恵
    • Organizer
      第8回Symphony
    • Place of Presentation
      ホテルメトロポリタン エドモント(東京都千代田区)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 体内時計の理解と生活習慣病やブルーライト弊害の予防2015

    • Author(s)
      羽鳥 恵
    • Organizer
      第8回日本薬学会関東支部若手シンポジウム
    • Place of Presentation
      日本大学薬学部キャンパス(千葉県船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 時間生物学の基礎―メラノプシンと概日リズム2015

    • Author(s)
      羽鳥 恵
    • Organizer
      Cataract Academic Seminar
    • Place of Presentation
      JPタワー ホール&カンファレンス(東京都千代田区)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The Circadian Clock and Melanopsin: a blue-light sensitive photopigment in mammalian retinal ganglion cells2015

    • Author(s)
      Megumi Hatori
    • Organizer
      Asia-ARVO 2015
    • Place of Presentation
      横浜
    • Year and Date
      2015-02-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 白内障と睡眠障害2014

    • Author(s)
      羽鳥 恵
    • Organizer
      一般財団法人白内障研究所 白内障研究所市民公開講座
    • Place of Presentation
      東京
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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