| Project/Area Number |
26892013
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 天然物化学 / 代謝産物 / フェアリー化合物 / プリン代謝 / 生合成 / Fairy chemical / AHX / AOH / ICA / metabolite / biosynthesis |
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| Outline of Final Research Achievements |
Fairy chemicals that cause fairy ring, 2-azahypoxanthine (AHX) and imidazole-4-carboxamide (ICA), were isolated form Lepista sordida. In plant, AHX were existed and metabolized to 2-aza-8-oxohypoxanthine (AOH). We examined the endogenous fairy chemicals in microorganisms. AHX and AOH were detected in plants and fungi. The metabolites of ｆairy chemicals in the plant were isolated, and then determined the structures. Currently, we are trying to identify the biosynthesis and metabolism enzymes. The yield increased production effect on the crop of AHX. An efficient AOH synthesis using resting cells was studyed.
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