Study of the perioperative epidural analgesia influence to the immunoresponse concern to the intestinal mucosal barrier in dogs.
Project/Area Number |
26892018
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Veterinary medical science
|
Research Institution | Yamaguchi University |
Principal Investigator |
ISERI toshie 山口大学, 共同獣医学部, 助教 (00453142)
|
Research Collaborator |
FUIJIMOTO yuka
KISHIMOTO miori
MIE keiichiro
OHASHI fumihito
AKIYOSHI hideo
ITOH hiroshi
NAKAICHI munekazu
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 硬膜外鎮痛 / 周術期麻酔 / 犬 / 獣医 / 麻酔 / 周術期ストレス / 獣医麻酔学 / リドカイン / 周術期管理 / 免疫抑制 |
Outline of Final Research Achievements |
This study evaluates that influence of perioperative epidural analgesia to the immunoresponse concern to the intestinal mucosal barrier function in dogs. Perfusion CT revealed that epidural analgesia decreased the parenchymal blood flow of the duodenum and pancreas, and vasodilated the celiac artery, significantly. However, the expression of mRNA cytokine (IL-6, IL-12p35 and IL-12p40) of the duodenum and colon were not difference significantly with/without epidural analgesia during operation. These results suggest that further study is necessary to evaluate long-term influence about epidural analgesia.
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Report
(3 results)
Research Products
(1 results)