Effects of prenatal exposure to passive smoking and genetic polymorphisms on attention deficit/hyperactivity disorders (ADHD) in Japanese children
| Project/Area Number |
26893002
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kobayashi Sumitaka 北海道大学, 環境健康科学研究教育センター, 特任助教 (10733371)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ADHD / 喫煙 / 遺伝環境交互作用 / 環境化学物質 / 妊婦 / 社会医学 / 疫学 / 公衆衛生学 / 受動喫煙 / 注意欠損多動性障害 |
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| Outline of Final Research Achievements |
I investigated the effects of maternal genetic polymorphisms and prenatal passive smoking in relation to children’s attention deficit/hyperactivity disorder (ADHD) in Japanese children at 8-year-old of age by means of nested case-control study. Totally, 1,491 participants (552 non-smokers, 812 passive smokers and 127 smokers) were included in the study between 2003 and 2007. Three groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester of pregnancy (cut-off = 0.21 and 11.48 ng/mL). We conducted data analysis using logistic regression models. Odds ratio of suspected ADHD of infants born from passive smokers was 1.17 (95%CI: 0.84-1.63) compared to infant born from non-smokers. Therefore, I considered that infants whose mothers passive-smoked during the third trimester had not increased ADHD risk at 8-year-old and not affected gene-environment interaction between maternal genetic polymorphisms and prenatal passive smoking to ADHD.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] 妊娠初期における北海道内女性労働者の記述疫学的考察2015
Author(s)
小林澄貴, 宮下ちひろ, 荒木敦子, 池野多美子, 伊藤佐智子, Houman Goudarzi, 花岡知之, 岸玲子
Organizer
平成27年度日本産業衛生学会北海道地方会（第95回北海道医学大会産業衛生分科会）
Place of Presentation
旭川建設労働者福祉センター (北海道・旭川市)
Year and Date
2015-10-17
Related Report
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[Presentation] Effects of maternal AHR, CYP1A1 and GSTM1 polymorphisms and dioxins on infant birth weight: The Hokkaido Study2015
Author(s)
Sumitaka Kobayashi, Chihiro Miyashita, Seiko Sasaki, Atsuko Araki, Fumihiro Sata, Susumu Ban, Jumboku Kajiwara, Takashi Todaka, Reiko Kishi
Organizer
27th Conference of the International Society for Environmental Epidemiology (ISEE2015)
Place of Presentation
Reboucas Conference Center, Sao Paulo （Brazil)
Year and Date
2015-08-30
Related Report
Int'l Joint Research
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