| Project/Area Number |
26893013
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 胎児 / バゾプレシン / 人工胎盤 / 早産児 / ヒツジ / バゾプレッシン |
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| Outline of Final Research Achievements |
We analyzed the cardiovascular responses to the low dose infusion of vasopressin using chronically instrumented premature fetal sheep (n=5). No significant difference in the tissue blood flow and vascular resistance of adrenal glands, kidneys, gut, heart and brain was found between before and after the vasopressin infusion.
We also succeeded to examine the correlation of the vascular resistance with resistance index detected by the Doppler ultrasonography before and after the vasopressin infusion in the premature fetal sheep (n=6), supported by the pumpless artificial placenta system. There was no significant correlation between the vascular resistance and resistance index in the middle cerebral and renal artery.
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