Elucidation of oral mucositis onset mechanism by saliva metabolome analysis and the oral flara genomics analysis

• Project/Area Number: 26893024
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: sakuma yoko 東北大学, 歯学研究科(研究院), 助教 (90735531)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 頭頚部がん / 放射線治療 / 化学療法 / 口腔粘膜炎 / 放射線療法 / 頭頸部がん

Outline of Final Research Achievements

Oral mucositis is one of the major adverse events of Intensity-modulated radiation therapy and chemotherapy for patients with head and neck cancer. However, standard care for the oral mucositis has not been established. In this study, we examined a genetic search method of oral flora which is said to be the cause of oral mucositis. This method revealed more accurate overview of oral flora compared with conventional cultivation. Therefore, it is thought that the genetic search method might be useful to clarify exacerbating or causative factor of oral mucositis.