| Project/Area Number |
26893029
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Ogawa Koichi 筑波大学, 医学医療系, 講師 (20733637)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脂肪肝 / 肝硬変 / 肝癌 / ローズマリー / シネオール / 肝星細胞 / 肝特異的PTENノックアウトマウス / 抗鬱作用 |
|---|
| Outline of Final Research Achievements |
The effective treatment of NASH and following tumorigenesis is not yet to be determined. We focused on the natural compound of Rosemary extract (RE), and tested its effect. The anititumor effect of 1,8-cineole was shown on huh-7 cell lines, and RE showed suppressing effect on activated liver stellate cell. But after 8 week’s oral treatment of RE on PTEN KO mouse resulted in the excess body weight and worsened liver fatty change, compered to that of control group. Rosemary has an anti-depressant and appetite promoting effect, and these could cause the adverse effects.
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