Investigation of transporters as atherosclerosis modifiers

• Project/Area Number: 26893044
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Mizuno Tadahaya 東京大学, 薬学研究科(研究院), 助教 (90736050)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: トランスポーター / 炎症 / SLCトランスポーター / 炎症制御 / インフラマソーム

Outline of Final Research Achievements

The study objective is identification and investigation of a transporter which modifies atherosclerosis. By data-mining, I identified a transporter that was greatly upregulated in atherosclerosis model. Further analysis revealed that the transporter expression was increased by several inflammatory stimuli, which indicates that the transporter modifies inflammatory response. Inflammation induces several diseases like atherosclerosis, so this study will be helpful for understanding of these diseases and establishment of a new therapeutic strategy.