Exploration and analysis of effector-like RNAs secreted by Helicobacter pylori

Research Project

Project/Area Number	26893046
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Bacteriology (including mycology)
Research Institution	The University of Tokyo
Principal Investigator	Kiga Kotaro 東京大学, 医科学研究所, 特任助教 (90738246)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	ピロリ菌 / sRNA / 機能性RNA / 胃がん / RNA / 細菌感染 / 胃癌
Outline of Final Research Achievements	Injection of virulence protein CagA of Helicobacter pylori into the host gastric cells is associated with the progression of stomach cancer. It was supposed that, in addition to CagA protein, other functional RNAs were injected into the host cells. Some bacterial RNAs were observed to be included in the host cells not via a needle-shaped secretion apparatus of H. pylori but via vesicles secreted from bacterial membrane.

Report

(3 results)