Research Project
Grant-in-Aid for Research Activity Start-up
Mast cells are known as effector cells in various allergic diseases and have been classified into connective tissue type (e.g. skin, blood vessel, and peritoneal cavity) and mucosal tissue type (e.g. lung and intestinal mucosa).In this research, we have found tissue specific gene expression patterns in mast cells and a surface molecule bearing inhibitory motif was strongly expressed in the skin mast cells but not in mast cells located in the other tissues.Mice lacking this molecule were sensitive to skin inflammations compared to wild type mice. These findings suggested that regulation of this molecule would be novel strategies for the suppression of skin inflammation.
All 2016 2015 2014
All Journal Article (11 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 11 results, Open Access: 9 results, Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results, Invited: 5 results) Book (10 results)
Sci Rep
Volume: 5 Issue: 1 Pages: 9750-9750
10.1038/srep09750
Current Opinion Rheumatology
Volume: 27 Issue: 4 Pages: 388-396
10.1097/bor.0000000000000192
Mediators Inflamm.
Volume: 427125 Issue: 1 Pages: 427125-427125
10.1155/2015/427125
Int. Immunol.
Volume: - Issue: 6 Pages: 307-314
10.1093/intimm/dxv004
Immunity
Volume: 42(2) Issue: 2 Pages: 279-293
10.1016/j.immuni.2015.01.015
Scientific Report
Volume: -
Int Immunol.
Volume: 40 Issue: 4 Pages: 530-541
10.1016/j.immuni.2014.01.014
Mediators of Inflammation
Volume: Article ID 427125 Pages: 1-9
ＰＬｏＳ Ｏｎｅ
Volume: 9 Issue: 10 Pages: e107492-e107492
10.1371/journal.pone.0107492
Exp Mol Med.
Volume: 46 Issue: 3 Pages: e83-e83
10.1038/emm.2014.7
