| Project/Area Number |
26893049
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Dokkyo Medical University (2015)
The University of Tokyo (2014) |
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Principal Investigator |
OBI SYOTARO 獨協医科大学, 医学部, 講師 (10734452)
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| Research Collaborator |
HASEGAWA TAKAAKI 獨協医科大学, 心臓血管内科, 研究員
|
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 機械的刺激 |
|---|
| Outline of Final Research Achievements |
Human cardiac fibroblast cells were exposed to cyclic stretch. Cyclic stretch induced the morphological change. Cyclic stretch increased the protein and mRNA expression level of aSMA. On the other hand, it decresed the protein expression level of collagen type1, fobronectin, BNP, and NEP. Human cardiac fibroblast expresses TRPV1, 2, 3, and 4. TRPV2 agonist and TRPV4 agonist increased the intracellular calcium flow, while TRPV1 agonist did no change it.
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