| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The ratios of IL-10-producing regulatory B cells, CD24(hi)CD27(+) B cells, and CD24(hi)CD38(hi) B cells were significantly decreased in peripheral blood of patients with CTCL. The numbers of them were significantly inversely correlated with serum LDH levels, one of the disease severity markers of CTCL. Thus, regulatory B cells might be associated with progression of CTCL.
The expression levels of VEGF-A in lesional skin and sera in patients with CTCL were significantly elevated. VEGF-A expression levels were correlated with CCL27 expression levels in lesional skin, one of the disease severity markers, and clinical and serological markers for pruritus. Thus, VEGF-A can be associated with disease progression and pruritus in CTCL.
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